Protein Info for NIAGMN_21240 in Escherichia coli ECRC102

Name: nupX
Annotation: Putative nucleoside permease NupX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 416 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 29 to 49 (21 residues), see Phobius details amino acids 67 to 81 (15 residues), see Phobius details amino acids 95 to 128 (34 residues), see Phobius details amino acids 173 to 195 (23 residues), see Phobius details amino acids 201 to 220 (20 residues), see Phobius details amino acids 259 to 286 (28 residues), see Phobius details amino acids 296 to 310 (15 residues), see Phobius details amino acids 354 to 380 (27 residues), see Phobius details amino acids 391 to 414 (24 residues), see Phobius details TIGR00804: nucleoside transporter, NupC family" amino acids 4 to 412 (409 residues), 498.5 bits, see alignment E=7.9e-154 PF01773: Nucleos_tra2_N" amino acids 8 to 81 (74 residues), 79.8 bits, see alignment E=2.5e-26 PF07670: Gate" amino acids 99 to 195 (97 residues), 56.3 bits, see alignment E=5.8e-19 PF07662: Nucleos_tra2_C" amino acids 201 to 410 (210 residues), 241.4 bits, see alignment E=1.3e-75

Best Hits

Swiss-Prot: 100% identical to NUPX_ECOLI: Putative nucleoside permease NupX (nupX) from Escherichia coli (strain K12)

KEGG orthology group: K03317, concentrative nucleoside transporter, CNT family (inferred from 100% identity to eco:b2161)

MetaCyc: 100% identical to putative nucleoside transporter (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Probable pyrimidine nucleoside transport protein associated with pseudouridine catabolism"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (416 amino acids)

>NIAGMN_21240 Putative nucleoside permease NupX (Escherichia coli ECRC102)
MDVMRSVLGMVVLLTIAFLLSVNKKKISLRTVGAALVLQVVIGGIMLWLPPGRWVAEKVA
FGVHKVMAYSDAGSAFIFGSLVGPKMDTLFDGAGFIFGFRVLPAIIFVTALVSILYYIGV
MGILIRILGGIFQKALNISKIESFVAVTTIFLGQNEIPAIVKPFIDRLNRNELFTAICSG
MASIAGSTMIGYAALGVPVEYLLAASLMAIPGGILFARLLSPATESSQVSFNNLSFTETP
PKSIIEAAATGAMTGLKIAAGVATVVMAFVAIIALINGIIGGVGGWFGFEHASLESIVGY
LLAPLAWVMGVDWSDANLAGSLIGQKLAINEFVAYLNFSPYLQTAGTLDAKTVAIISFAL
CGFANFGSIGVVVGAFSAVAPHRAPEIAQLGLRALAAATLSNLMSATIAGFFIGLA