Protein Info for NIAGMN_16450 in Escherichia coli ECRC102

Name: ttdA
Annotation: L(+)-tartrate dehydratase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00722: hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type
  • amino acids 14 to 287 (274 residues), 408.1 bits, E=7.8e-127
• PF05681: Fumerase
  • amino acids 16 to 284 (269 residues), 277.3 bits, E=6.5e-87

Best Hits

Swiss-Prot: 100% identical to TTDA_ECO57: L(+)-tartrate dehydratase subunit alpha (ttdA) from Escherichia coli O157:H7

KEGG orthology group: K03779, L(+)-tartrate dehydratase alpha subunit [EC: 4.2.1.32] (inferred from 99% identity to eco:b3061)

MetaCyc: 99% identical to L(+)-tartrate dehydratase subunit alpha (Escherichia coli K-12 substr. MG1655)
L(+)-tartrate dehydratase. [EC: 4.2.1.32]

Predicted SEED Role

"L(+)-tartrate dehydratase alpha subunit (EC 4.2.1.32)" (EC 4.2.1.32)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.32

Use Curated BLAST to search for 4.2.1.32

Protein Sequence (303 amino acids)

>NIAGMN_16450 L(+)-tartrate dehydratase subunit alpha (Escherichia coli ECRC102)
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNM
QKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATIKAPLRHNAVEIFDE
VNTGKNTGSGVPWVTWDIVPDGDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFE
NISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTR
SAL