Protein Info for NIAGMN_15625 in Escherichia coli ECRC102

Name: nanK
Annotation: N-acetylmannosamine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to NANK_ECO57: N-acetylmannosamine kinase (nanK) from Escherichia coli O157:H7

KEGG orthology group: K00885, N-acylmannosamine kinase [EC: 2.7.1.60] (inferred from 100% identity to eok:G2583_3942)

MetaCyc: 97% identical to N-acetylmannosamine kinase (Escherichia coli K-12 substr. MG1655)
N-acylmannosamine kinase. [EC: 2.7.1.60]

Predicted SEED Role

"N-acetylmannosamine kinase (EC 2.7.1.60)" in subsystem Sialic Acid Metabolism (EC 2.7.1.60)

MetaCyc Pathways

superpathway of N-acetylneuraminate degradation (22/22 steps found)
superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (6/6 steps found)
N-acetylneuraminate and N-acetylmannosamine degradation I (4/4 steps found)
CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (2/5 steps found)
superpathway of CMP-sialic acids biosynthesis (4/15 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.60

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>NIAGMN_15625 N-acetylmannosamine kinase (Escherichia coli ECRC102)
MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVA
IASTGIIRDGSLLALNPHNLGGLLHFPLVKTLGQLTDLPTIAINDAQAAAWAEYQALEGD
ITDMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASG
RGIAAAAQGELAGADAKTIFMRAGQGDEQAQQLIHRSAHVLARLIADIKATTDCQCVVVG
GSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL