Protein Info for NIAGMN_14410 in Escherichia coli ECRC102

Annotation: SAM-dependent methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 352 PF21212: Dimerisation2-like_dom" amino acids 15 to 83 (69 residues), 48.3 bits, see alignment E=2.7e-16 PF13847: Methyltransf_31" amino acids 177 to 292 (116 residues), 28.2 bits, see alignment E=3.6e-10 PF00891: Methyltransf_2" amino acids 179 to 332 (154 residues), 64.4 bits, see alignment E=2.5e-21 PF13649: Methyltransf_25" amino acids 183 to 277 (95 residues), 32.9 bits, see alignment E=2.2e-11 PF08242: Methyltransf_12" amino acids 183 to 279 (97 residues), 34.9 bits, see alignment E=5.2e-12

Best Hits

KEGG orthology group: None (inferred from 99% identity to eum:ECUMN_3939)

Predicted SEED Role

"Biotin synthesis protein BioC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (352 amino acids)

>NIAGMN_14410 SAM-dependent methyltransferase (Escherichia coli ECRC102)
MYEQDSLSALDAITEAQRIAFAPMLFQTALCLRNAGVLSYLDRQGKHGATLADITEHSHI
NEYATSVLLDMGLSGRIITCKEGIYYLAKIGHYLLHDTMTRVNMDFTQDVCYQGLFFLAD
SLNEGKPSGLKVFGDWSTIYPALSQLPDAARESWFAFDHYYSDGAFNAALPYVFANNPTT
LYDVGGNTGKWALRCCKYNENIAVTLLDLPQQIVLAKENIANAGFSDRIDFHAVDMLSDA
PLPGEADIWWMSQFLDCFSPEQIISILSKIASVMKPGAKVCIMELFWDAQRFEAASFSLN
ASSLYFTCMANGNSRFYSAEKFYDYLNKAGFQVAERHDNLGVGHTLLICQKK