Protein Info for NIAGMN_14225 in Escherichia coli ECRC102

Annotation: DUF4049 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 PF21661: DUF6860" amino acids 40 to 164 (125 residues), 282.3 bits, see alignment E=3.5e-89 PF13258: DUF4049" amino acids 209 to 533 (325 residues), 558.1 bits, see alignment E=6.5e-172

Best Hits

Swiss-Prot: 84% identical to YHIL_ECOLI: Putative uncharacterized protein YhiL (yhiL) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ece:Z4888)

Predicted SEED Role

"FIG00638558: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (536 amino acids)

>NIAGMN_14225 DUF4049 domain-containing protein (Escherichia coli ECRC102)
MKVFHNIFKYISSNHQDKHSDKVNNHQHHGKVDKKHRSEIVEIDKLDKHSQIDNDFGLHI
IYFLQHGCWNVTEHSPQIEKIWFYNSEPSIDIKEYNSFADNTTDTFIFTIIPDNNHVIKL
SSPITVTIERKDGYYFINFSGDKSDIIYKVDGFSIKERNFFTLLSGNFKPDWRWAVSKET
FTKEKFDSYVESVFSKIDFYKQCGVINPQNANTAYFGDTDGRVGAVLYALLVSGHIGIRE
KGWSLLCDLLKHEDMASFAYENKKLKKLFTLLDKRDMILNELHQHVFLKGDAITPCIFLG
DHTGDRFSTIFGDKYILTLLNSMRNMEGNKDSRINKNVVVLAGNHEINFNGNYSARLANH
KLSSGDTYNLIKTLDVCNYDSERHVLTSHHGIIRDEENKCYCLGALQVPFNQMKNPTDPE
ELAYIFNKKHKQHMDDHLFHLIRSNTMAPTPVYADYLNNTTDFRPDPEDIFKCGQTLECG
DPRKNIRQKYGHHGLGVNQNQQFDNGVMGLNSRMAVFDENKKIIGSSSGLSCFQPH