Protein Info for NIAGMN_13790 in Escherichia coli ECRC102

Name: bisC
Annotation: biotin sulfoxide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 777 PF18364: Molybdopterin_N" amino acids 12 to 52 (41 residues), 26.9 bits, see alignment 5.9e-10 TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 13 to 775 (763 residues), 1093.4 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 56 to 517 (462 residues), 305.1 bits, see alignment E=9.8e-95 PF01568: Molydop_binding" amino acids 636 to 741 (106 residues), 85.8 bits, see alignment E=3.1e-28

Best Hits

Swiss-Prot: 99% identical to BISC_ECOLI: Biotin sulfoxide reductase (bisC) from Escherichia coli (strain K12)

KEGG orthology group: K08351, biotin sulfoxide reductase [EC: 1.-.-.-] (inferred from 99% identity to eco:b3551)

MetaCyc: 99% identical to biotin sulfoxide reductase (Escherichia coli K-12 substr. MG1655)
L-methionine (S)-S-oxide reductase. [EC: 1.8.4.13]; 1.8.4.- [EC: 1.8.4.13]

Predicted SEED Role

"Anaerobic dimethyl sulfoxide reductase chain A (EC 1.8.5.3)" (EC 1.8.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.-.-.-, 1.8.5.3

Use Curated BLAST to search for 1.-.-.- or 1.8.4.13 or 1.8.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (777 amino acids)

>NIAGMN_13790 biotin sulfoxide reductase (Escherichia coli ECRC102)
LTNSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFP
MVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSN
GVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSD
VVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVA
PHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEIC
GVNAEKIRELAAIFHQNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLS
YHFANGGNPTRRAAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMDRHFPD
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDL
TMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFY
NVARQRGASQQVELPPFTEFWQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASGKI
EIFSQRIADYAYPDCPGHPMWLVPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELY
AVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDL
DLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS