Protein Info for NIAGMN_05130 in Escherichia coli ECRC102

Name: kdpD
Annotation: two-component system sensor histidine kinase KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 894 transmembrane" amino acids 399 to 419 (21 residues), see Phobius details amino acids 425 to 443 (19 residues), see Phobius details amino acids 449 to 466 (18 residues), see Phobius details amino acids 477 to 498 (22 residues), see Phobius details PF02702: KdpD" amino acids 21 to 230 (210 residues), 323.1 bits, see alignment E=1.8e-100 PF13493: DUF4118" amino acids 403 to 508 (106 residues), 102.6 bits, see alignment E=2.5e-33 PF13492: GAF_3" amino acids 527 to 644 (118 residues), 40.8 bits, see alignment E=7e-14 PF00512: HisKA" amino acids 664 to 730 (67 residues), 48.2 bits, see alignment 2.3e-16 PF02518: HATPase_c" amino acids 776 to 882 (107 residues), 94.8 bits, see alignment E=1.1e-30

Best Hits

Swiss-Prot: 100% identical to KDPD_ECOLI: Sensor protein KdpD (kdpD) from Escherichia coli (strain K12)

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to eck:EC55989_0679)

MetaCyc: 100% identical to sensor histidine kinase KdpD (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (894 amino acids)

>NIAGMN_05130 two-component system sensor histidine kinase KdpD (Escherichia coli ECRC102)
MNNEPLRPDPDRLLEQTAAPHRGKLKVFFGACAGVGKTWAMLAEAQRLRAQGLDIVVGVV
ETHGRKDTAAMLEGLAVLPPKRLAYRGRHISEFDLDAALARRPALILMDELAHSNAPGSR
HPKRWQDIEELLEAGIDVFTTVNVQHLESLNDVVSGVTGIQVRETVPDPFFDAADDVVLV
DLPPDDLRQRLKEGKVYIAGQAERAIEHFFRKGNLIALRKLALRRTADRVDEQMRAWRGH
PGEEKVWHTRDAILLCIGHNTGSEKLVRAAARLASRLGSVWHAVYVETPALHRLPEKKRR
AILSALRLAQELGAETATLSDPAEEKAVVRYAREHNLGKIILGRPASRRWWRRETFADRL
ARIAPDLDQVLVALDEPPARTINNAPDSRSFKDKWRVQIQGCVVAAALCAVITLIAMQWL
MAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVVSFDLFFIAPRGTLAVSDVQYLLT
FAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGRSPQDIAATSEQFIA
STFHARSQVLLPDDNGKLQPLTHPQGMTPWDDAIAQWSFDKGLPAGAGTDTLPGVPYQIL
PLKSGEKTYGLVVVEPGNLRQLMIPEQQRLLETFTLLVANALERLTLTASEEQARMASER
EQIRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQHVLNTTRLVNN
LLDMARIQSGGFNLKKEWLTLEEVVGSALQMLEPGLSSPINLSLPEPLTLIHVDGPLFER
VLINLLENAVKYAGAQAEIGIDAHVEGENLQLDVWDNGPGLPPGQEQTIFDKFARGNKES
AVPGVGLGLAICRAIVDVHGGTITAFNRPEGGACFRVTLPQQTAPELEEFHEDM