Protein Info for MPMX26_03130 in Acinetobacter radioresistens SK82

Annotation: Arsenical-resistance protein Acr3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 43 to 62 (20 residues), see Phobius details amino acids 82 to 103 (22 residues), see Phobius details amino acids 109 to 131 (23 residues), see Phobius details amino acids 138 to 161 (24 residues), see Phobius details amino acids 180 to 204 (25 residues), see Phobius details amino acids 222 to 240 (19 residues), see Phobius details amino acids 252 to 273 (22 residues), see Phobius details amino acids 286 to 309 (24 residues), see Phobius details amino acids 315 to 338 (24 residues), see Phobius details TIGR00832: arsenical-resistance protein" amino acids 6 to 334 (329 residues), 422.6 bits, see alignment E=6e-131 PF01758: SBF" amino acids 52 to 247 (196 residues), 185.3 bits, see alignment E=5e-59

Best Hits

Swiss-Prot: 61% identical to ARSB_BACSU: Arsenite resistance protein ArsB (arsB) from Bacillus subtilis (strain 168)

KEGG orthology group: K03325, arsenite transporter, ACR3 family (inferred from 88% identity to aby:ABAYE3659)

MetaCyc: 61% identical to arsenite efflux transporter Acr3 (Bacillus subtilis)
TRANS-RXN0-264

Predicted SEED Role

"Arsenical-resistance protein ACR3" in subsystem Arsenic resistance

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (346 amino acids)

>MPMX26_03130 Arsenical-resistance protein Acr3 (Acinetobacter radioresistens SK82)
MSEKRLSFLDRNLTLWIFIAMALGIAIGNFFPQASVALDQLSINSVNIPIAVGLILMMYP
PLAKVNYVTLPQVFKDKKTLTLSLIQNWLIAPVMMFALAIIFLHSYPEYMTGVILIGLAR
CIAMVLVWNGLACGDNQYVAALVAFNSIFQILFFSTYAWLFLTFLPPYFGVASQVINVDF
WTITHAVLVYLGIPFLLGFLTRWILVKQKGVEWYETKFIPKISPLSLMALLFTILAMFSL
KGGDVVSLPLEVLRIAVPLTIYFVLMFFISFFMSKWMGNDYPKTTAIAFTAAGNNFELSL
AVAIATFGIASPVAFTTIIGPLVEVPVLIALVSVSLWLRKKVFKEA