Protein Info for MPMX26_03117 in Acinetobacter radioresistens SK82

Annotation: Copper-exporting P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 791 transmembrane" amino acids 140 to 158 (19 residues), see Phobius details amino acids 169 to 188 (20 residues), see Phobius details amino acids 202 to 226 (25 residues), see Phobius details amino acids 238 to 257 (20 residues), see Phobius details amino acids 392 to 414 (23 residues), see Phobius details amino acids 420 to 443 (24 residues), see Phobius details amino acids 737 to 757 (21 residues), see Phobius details amino acids 763 to 784 (22 residues), see Phobius details PF04945: YHS" amino acids 21 to 63 (43 residues), 48.2 bits, see alignment 2.2e-16 PF19335: HMBD" amino acids 95 to 120 (26 residues), 54.5 bits, see alignment (E = 2.2e-18) TIGR01511: copper-translocating P-type ATPase" amino acids 183 to 787 (605 residues), 586.4 bits, see alignment E=1.3e-179 TIGR01525: heavy metal translocating P-type ATPase" amino acids 202 to 786 (585 residues), 619.5 bits, see alignment E=1.4e-189 TIGR01494: HAD ATPase, P-type, family IC" amino acids 246 to 755 (510 residues), 295.5 bits, see alignment E=1.1e-91 PF00122: E1-E2_ATPase" amino acids 275 to 457 (183 residues), 188.6 bits, see alignment E=1.9e-59 PF00702: Hydrolase" amino acids 474 to 691 (218 residues), 120.1 bits, see alignment E=4.1e-38

Best Hits

Swiss-Prot: 58% identical to COPA_LEGPH: Copper-exporting P-type ATPase (copA) from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 78% identity to aby:ABAYE3205)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (791 amino acids)

>MPMX26_03117 Copper-exporting P-type ATPase (Acinetobacter radioresistens SK82)
MLDQKNHNQDHMTQATTDVLKDPVCGMTVTEESKYHEEFKGKTYFFCSDKCQSKFHSSPV
QYIAKPATTTADAHTQHHQTTQSVNDASTTGTTIYTCPMHPEIRQDHPGNCPKCGMTLEP
LIPELEEDENPELRDFRRRFWWTLPLTIVVTFLAMFGHQLNLFDMAVQSWIELVLSLPIV
LWAGWPFFSRGWQSVVNRSPNMWTLIGLGTGAAFIYSVVATIAPQIFPDSFISMGRVAVY
FEASAVIISLTLLGQILELKARSQTSAAIKSLLGLAPKTARRILPDGTEEDVPLTHVHVG
DLLRIRPGEKVPVDGVVTDGSSSLDESMLTGEPLPITKRIGDKVIGATLNTNGSLIMRSE
KIGSSTMLSQIVQMVAQAQRSRAPMQRMADQVAGWFVMAVVAIALLTFFGWGLFGPEESS
WVYALINAVAVLIIACPCALGLATPMSIMVATGQGATHGVLFRDAAAIENLRKIDTLIID
KTGTLTEGRPVFDRVVAASGFDESEVLRLAASLDQGSEHPLAEAIVNAAHERGLSLETPD
NFESGSGIGVRGQVGDRQLALGNTALMEQLGISVQSLIPQAEELRSEGASVMYLAVDGQL
AGLLAVSDPIKTSTPEALATLKEAGLRIVMATGDGLTTARTVAARLGIDEVHGEVKPADK
LELVSKLQKEGRIVAMAGDGINDAPALAKADVGIAMGTGTDVAMNSAQVTLVKGDLRGIA
VARSLSEATVGNMKQNLMFAFLYNALGIPIAAGVLYPFTGWLLSPMIAALAMSLSSASVI
TNALRLRHKKL