Protein Info for MPMX26_03011 in Acinetobacter radioresistens SK82

Annotation: Multidrug resistance protein MdtA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 368 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 45 to 351 (307 residues), 226.2 bits, see alignment E=2.5e-71 PF16576: HlyD_D23" amino acids 54 to 261 (208 residues), 50.7 bits, see alignment E=3e-17 PF13533: Biotin_lipoyl_2" amino acids 60 to 106 (47 residues), 31.4 bits, see alignment 2.6e-11 PF13437: HlyD_3" amino acids 170 to 264 (95 residues), 45.4 bits, see alignment E=2.3e-15

Best Hits

KEGG orthology group: None (inferred from 72% identity to acd:AOLE_00140)

Predicted SEED Role

"RND efflux membrane fusion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (368 amino acids)

>MPMX26_03011 Multidrug resistance protein MdtA (Acinetobacter radioresistens SK82)
MSLTKSALVSLIFMCYLTLGGCSREAPQTEEIPYVMVAQPLTTHHEQKSYAGEVQARQQT
ALAFRVGGQVTARLAEVGDRVRAGQVLARLDVSDAQLQSNAARAQLESAQAALKIAADEL
QRFRQLLPMNAVSRSQYDAVENQYKSAESAYRQAQSNYQVSTNQTRYNQLQANRAGVITE
RNIEVGQVVAAGQVAYQLAIDGDRDVVIGIPEQTTSAIKVGQTAWVTLWSQPQARLAAYV
REISPAADESRTFKVKVALREGPSAIQLGQSARVFFDYSQPNVLSVPLSSVSAHEKQPYI
WVLQQDQRIHKVPVQLGAYGRDSVPVLSGLKAGDWVVIGGVHLLHDKQRIHPVDRNNRPV
KLAAGAQP