Protein Info for MPMX26_02955 in Acinetobacter radioresistens SK82

Annotation: Multidrug export protein MepA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 50 to 79 (30 residues), see Phobius details amino acids 94 to 117 (24 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 168 to 191 (24 residues), see Phobius details amino acids 197 to 219 (23 residues), see Phobius details amino acids 246 to 271 (26 residues), see Phobius details amino acids 291 to 313 (23 residues), see Phobius details amino acids 326 to 345 (20 residues), see Phobius details amino acids 365 to 385 (21 residues), see Phobius details amino acids 397 to 417 (21 residues), see Phobius details amino acids 424 to 443 (20 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 23 to 424 (402 residues), 250.4 bits, see alignment E=1.5e-78 PF01554: MatE" amino acids 23 to 184 (162 residues), 115.2 bits, see alignment E=2.5e-37 amino acids 252 to 413 (162 residues), 104.4 bits, see alignment E=5.1e-34 PF14667: Polysacc_synt_C" amino acids 138 to 224 (87 residues), 31.5 bits, see alignment E=1.8e-11

Best Hits

Swiss-Prot: 44% identical to YOEA_BACSU: Probable multidrug resistance protein YoeA (yoeA) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 82% identity to aci:ACIAD3554)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (455 amino acids)

>MPMX26_02955 Multidrug export protein MepA (Acinetobacter radioresistens SK82)
MAPHQTTIQQQKLWKTFLVFLLPLIATNILQNLSGTINTIFVGQMMGVEAIAAVSVFFPI
LFCLMAFVIGLSAGATVLVGQAWGAQNIQKVRCVVGSTLFMTLIGGIIVALLGVIFAEHI
LLALGTDPAVMHLSLPYVRWMLAGSPLLFIYIIYTSILRGVGDSVTPLIALGMTSLIGLM
ITPILIAGYFGLPKMGIIAPAIATIVGYLAVLGFLAVYLNKKHHPLRPDRELFSYIRHQP
KLSKIILRLGIPTGIQMVTTSVAGLVIVGLVNRFGAHATAAYGAVNQVLNYIQFPALSIG
IAASIFAAQAIGAGKNDLLSRVSRTALGMNFVITGILVILGYLFSKYLMALFITDPEVVE
LGQQLLFIVLWSILFFGASAIFASIMRASGTVTVPMLINIFAILAIELPCAYWFSQIWGL
KGIWYAYALAFVSLCILQGLYYQFVWKKKTVEVLI