Protein Info for MPMX26_02892 in Acinetobacter radioresistens SK82

Annotation: UvrABC system protein A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 943 TIGR00630: excinuclease ABC subunit A" amino acids 6 to 927 (922 residues), 1453.1 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 132 to 235 (104 residues), 125.5 bits, see alignment E=3.5e-40 PF17755: UvrA_DNA-bind" amino acids 293 to 400 (108 residues), 121.4 bits, see alignment E=8.9e-39 PF00005: ABC_tran" amino acids 780 to 863 (84 residues), 26.5 bits, see alignment E=3.6e-09

Best Hits

Swiss-Prot: 70% identical to UVRA_PSEAE: UvrABC system protein A (uvrA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 91% identity to abn:AB57_3742)

MetaCyc: 68% identical to UvrABC excision nuclease subunit A (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (943 amino acids)

>MPMX26_02892 UvrABC system protein A (Acinetobacter radioresistens SK82)
MSQSHIRIRGARTHNLKNVSLDIPRDKFVVITGLSGSGKSSLAFDTLYAEGQRRYVESLS
AYARQFLSQMEKPEVDAIEGLSPAIAIEQKSTSHNPRSTVGTITEIYDYLRLLYARVGTP
YCPEHDLPMVAQTVSEMVDAVKALPEGTALMLLAPVVRERKGEYSTLFEQLQSQGFVRAR
VDGEIIEIDTPPELDKKKKHTIEVIVDRFKVRDDLGNRIAESFETALRLGGDLAVLSWMK
DEHPDRVFSAKHSCPDCDRAVGDLEPRLFSFNNPFGACPACDGLGTRSHFSADKLIHNPE
LSISQGAIRGWDRQRPYYYSMLQKVAAHYDYSLETPWKDLGKDIQKKFLYGTGREKIDLS
YVDERGRRHNRVMPFEGVLPHLERRYRETESNYVRDDLSQYLSNAACDVCDGSRLNEISR
NVKILDHTISQITRMSIGDAAHYYEHLHLEGAKGEIGDKIFKEIRERLHFLVSVGLNYLS
LARSAETLSGGEAQRIRLASQIGAGLMGVMYVLDEPSIGLHQRDNDRLLQTLIRLRDLGN
TVLVVEHDEDAIRAADHIIDIGPGAGVHGGYVIAEGTADELCQHKDSLTGKYLSGELKIA
VPQQRVQPPKPEKQIKLLGASGHNLKNVDLTIPLGVMTCVTGVSGSGKSTLINRTLLPLA
ATQLNGATTLTPEKFDSIDGLQFLDKVVDIDQSPIGRTPRSNPATYTGVFTPIRELFAQT
QEAKARGYSAGRFSFNVKGGRCEACEGDGMIKVAMHFLPDMYVPCDACHGKRYNRETLEV
GYKGKNISDVLEMTVEDAAAFFEAIPVIHRRLETLTQVGLGYIRLGQSATTLSGGEAQRV
KLARELAKRDTGKTLYVLDEPTTGLHFHDIAKLLDILHELRNKGNTIVVIEHNLDVIKTA
DWVVDLGPEGGSGGGQIIATGTPEEVAEVAISHTGRFLKPLLK