Protein Info for MPMX26_02490 in Acinetobacter radioresistens SK82

Annotation: Xanthine permease XanP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 transmembrane" amino acids 28 to 57 (30 residues), see Phobius details amino acids 63 to 80 (18 residues), see Phobius details amino acids 90 to 113 (24 residues), see Phobius details amino acids 121 to 139 (19 residues), see Phobius details amino acids 150 to 168 (19 residues), see Phobius details amino acids 188 to 206 (19 residues), see Phobius details amino acids 218 to 236 (19 residues), see Phobius details amino acids 256 to 278 (23 residues), see Phobius details amino acids 344 to 365 (22 residues), see Phobius details amino acids 371 to 392 (22 residues), see Phobius details amino acids 401 to 421 (21 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 28 to 450 (423 residues), 419.3 bits, see alignment E=1.8e-129 PF00860: Xan_ur_permease" amino acids 29 to 420 (392 residues), 341.4 bits, see alignment E=3e-106 TIGR03173: xanthine permease" amino acids 33 to 452 (420 residues), 427.7 bits, see alignment E=4.1e-132

Best Hits

Swiss-Prot: 54% identical to XANP_ECO57: Xanthine permease XanP (xanP) from Escherichia coli O157:H7

KEGG orthology group: K03458, nucleobase:cation symporter-2, NCS2 family (inferred from 90% identity to abc:ACICU_03084)

MetaCyc: 54% identical to xanthine:H+ symporter XanP (Escherichia coli K-12 substr. MG1655)
RXN-5076

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (456 amino acids)

>MPMX26_02490 Xanthine permease XanP (Acinetobacter radioresistens SK82)
MSDLNTSSDQNERLDLVYGLNDRPRPLIAFLAALQHLLAIIVPIVTPGLLICLALGVSRE
DTNMILSMSLVISGIATFLQCKKVGPFGAGLLIVQGTSFNFIGPIIGIGSAMVASGTPVE
AVMAAIFGVVIAGSFIEMGVSRILPWVKKLITPLVTGIVVLLIGLTLIKEGLISMGGGYQ
AMESKTFASADNLIMSCTVLAIIILLNRMRAVWIKSSAILIALVAGYILAGFMGYLDFST
LEEAPLIQIPTPMHFGLSFSWSLFIPMAFIYLVTSLEAIGDITATSKLSNQPVDGDSWMQ
RIKGGVLVNGANSLLAGLFNTFPSSVFAQNNGVIQLTGVASRYVGLWIAIMLIILGLFPA
VAGIIQAVPQAVLGGAVMVMFGAVAASGVNILSGIQLDRRALLIIAISLALGLGVAQVPQ
ILEHLPELFKNIFSSGVATGGIAALILNIVLPETRK