Protein Info for MPMX26_01914 in Acinetobacter radioresistens SK82

Annotation: Acetyl-S-ACP:malonate ACP transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 559 PF16957: Mal_decarbox_Al" amino acids 12 to 559 (548 residues), 980.2 bits, see alignment E=1.2e-299 TIGR01110: malonate decarboxylase, alpha subunit" amino acids 12 to 559 (548 residues), 1003.4 bits, see alignment E=1.2e-306

Best Hits

KEGG orthology group: K13929, malonate decarboxylase alpha subunit [EC: 2.3.1.187] (inferred from 92% identity to aci:ACIAD1753)

MetaCyc: 78% identical to malonate decarboxylase acetyl-[acp]:malonate-[acp] transferase component (Klebsiella pneumoniae)
Biotin-independent malonate decarboxylase. [EC: 4.1.1.88]; Acetyl-S-ACP:malonate ACP transferase. [EC: 4.1.1.88, 2.3.1.187]

Predicted SEED Role

"Malonate decarboxylase alpha subunit" in subsystem Malonate decarboxylase

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.88

Use Curated BLAST to search for 2.3.1.187 or 4.1.1.88

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (559 amino acids)

>MPMX26_01914 Acetyl-S-ACP:malonate ACP transferase (Acinetobacter radioresistens SK82)
MEGSVQNKERIWTKRRHAKQLKLEMAAKYADGCIIPAEDIIKVLEILITPGDKVVLEGNN
QKQADFLSRSLIQVNPEILHDLHMIMPSVGRPEHLDLFEKGIARKLDFSFAGTQSLRISQ
LIEDGLLEVGAIHTYIELYSRLLVDLIPNVVLSAGFMADRQGNIYTGPSTEDSPALIEPA
AFSDGIVIVQVNELVDDVTDLPRVDIPASWVDFIVVADKPFYIEPLFTRDPKHIKPVHIL
MAMMAIRGIYERHQVQSLNHGIGFNTAAIELILPTYGESLGLKGKICRNWTLNPHPTLIP
AIETGWVESVHCFGTELGMEKYIAARPDVFFTGRDGSLRSNRMMCQLAGQYAVDLFIGAT
LQVDGSGNSSTVTKGRLAGFGGAPNMGHDPRGRRHATPAWLDMRTTDQTDTDTYLARGKK
LVVQMVETFQEGGKPTFVNTLDAVGVAQKAGMALAPIMIYGDDVTHLLTEEGIAYLYKAR
SMQEREEMIAAVAGVTDIGLNHNPKTTERLRQEGLVVFPEDLGIRRTDATRELLAAKNIA
ELVSWSDGLYQPPAKFRSW