Protein Info for MPMX26_01709 in Acinetobacter radioresistens SK82

Annotation: Sensor protein CzcS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 469 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 162 to 185 (24 residues), see Phobius details TIGR01386: heavy metal sensor kinase" amino acids 6 to 458 (453 residues), 379.7 bits, see alignment E=1.2e-117 PF00672: HAMP" amino acids 180 to 232 (53 residues), 27.1 bits, see alignment 6.5e-10 PF00512: HisKA" amino acids 237 to 301 (65 residues), 48 bits, see alignment E=1.6e-16 PF02518: HATPase_c" amino acids 347 to 459 (113 residues), 60.1 bits, see alignment E=4.2e-20

Best Hits

Predicted SEED Role

"Heavy metal sensor histidine kinase" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (469 amino acids)

>MPMX26_01709 Sensor protein CzcS (Acinetobacter radioresistens SK82)
MSIFRHSLAVRLSLSFIGIACAVFLAIGLLAYNGMDQVLKRQQDEALRARVERLELLIQN
SSDLNSLIQRPKLYENMLGNQDNLLILKNQNGTALIYINPLQIHIPILPKAEQTWLIDNK
KQQATTRLAWKTINYQGQQYLLIAGKQFDEREQVLYSFALKLAGYIGLGILTVCILSALV
SYYGLAPLRDLSEQTRLINIQKLNQRVSETSQSDEIRLLSTAMNSMLERIEQGYQQLSRF
SEDMAHEFRTPLNNLIGQTQILLSQDREKADYQDLLFSHLEEYERLKRMVENMLFLARAD
HSQNSLSIIEINLKSSLNELLAYFELIAEEKNLQINSRLKITFIHADYLLFQRAVSNLLN
NAIEYSTENGHISIIAERITLAGKIYNAIHVLTHDVYIAEQHLPHLFERFYQCDPARHQQ
GRSGGLGLAIVQSIMSVHEGITEVKNMPEGVRFSLYFPEHLAGNSVNRK