Protein Info for MPMX26_00998 in Acinetobacter radioresistens SK82

Annotation: Serine endoprotease DegS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 393 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details PF00089: Trypsin" amino acids 112 to 269 (158 residues), 71 bits, see alignment E=3.4e-23 PF13365: Trypsin_2" amino acids 115 to 248 (134 residues), 119.8 bits, see alignment E=4.1e-38 PF00595: PDZ" amino acids 285 to 363 (79 residues), 49.9 bits, see alignment E=8.5e-17 PF13180: PDZ_2" amino acids 289 to 375 (87 residues), 62.1 bits, see alignment E=1.3e-20 PF17820: PDZ_6" amino acids 310 to 364 (55 residues), 50.1 bits, see alignment 4.7e-17

Best Hits

KEGG orthology group: K04691, serine protease DegS [EC: 3.4.21.-] (inferred from 85% identity to aby:ABAYE1136)

Predicted SEED Role

"Outer membrane stress sensor protease DegS" in subsystem Proteolysis in bacteria, ATP-dependent

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (393 amino acids)

>MPMX26_00998 Serine endoprotease DegS (Acinetobacter radioresistens SK82)
MRRTFAWLPWVLLVIVIISFIGWQKFHQPKAPVAADGVKMPAEKVEPLIDTSRSGGVVSY
NAAVKVAAPAVVNIFTTQKVRQMNHPLLNDPAFREFFGDQLPDQFNSQQNENSLGSGVIV
RPDGYILTNNHVVAQAEQIVVALNDGRRAEAKIIGTDPDTDLAVIKIELDKLPVLPFKLS
GNEVGDVVLAIGNPFGVGQTVTQGIISATGRSDLGINTYEDFIQTDAAINPGNSGGALID
VAGNLIGVNTAIFSQTGGSLGIGFAIPAKVCQQVLNAILKDGRVVRGWLGISLVPPAQTD
VLAPREPGVVVAGVLGNGPAAKAGVKVGDRILKVNNEQITSTSHLINYVALQAPNSTIQL
LVEREGKQQTLNVNVGEREVQNQDSQFIPLPRR