Protein Info for MPMX26_00889 in Acinetobacter radioresistens SK82

Annotation: NADPH-dependent curcumin reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16884: ADH_N_2
  • amino acids 8 to 113 (106 residues), 140.8 bits, E=2.2e-45
• PF00107: ADH_zinc_N
  • amino acids 159 to 299 (141 residues), 65.7 bits, E=6e-22
• PF13602: ADH_zinc_N_2
  • amino acids 192 to 337 (146 residues), 40 bits, E=1.2e-13

Best Hits

Swiss-Prot: 65% identical to CURA_ECOLI: NADPH-dependent curcumin reductase (curA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 97% identity to spu:759392)

MetaCyc: 65% identical to NADPH-dependent curcumin/dihydrocurcumin reductase (Escherichia coli K-12 substr. MG1655)
RXN0-6676; RXN0-6677

Predicted SEED Role

"Putative oxidoreductase YncB"

MetaCyc Pathways

• curcumin degradation (2/2 steps found)

Protein Sequence (339 amino acids)

>MPMX26_00889 NADPH-dependent curcumin reductase (Acinetobacter radioresistens SK82)
MKTVINQRIVLAKRPVGEPKHSDFRIEQVELNELKQGEILLKTIYLSLDPYMRGRMSDAP
SYAAPVEIGEVMVGGTVSQVVASKNPKFKEGEWVLSGNGWQGYAISNGTACQSLGMQPEH
PSWALGILGMPGFTAYMGLLDIGQPKAGETLVVAAATGPVGATVGQIGKLKGCRVVGIAG
EPEKCRYAVEELGFDACINHHDENFAEQLQQAAPNGIDIYYENVGGKVFDAVWPLLNSAA
RVPVCGVVSQYNATEQAQGPDRLPGFISTLLKKRIRMQGFIIFDDYGSQYPEFYQQMSEW
LKDGKIKYKEHMVQGLDNTINAFNGMLKGENFGKVVVKI