Protein Info for MPMX26_00808 in Acinetobacter radioresistens SK82

Annotation: Protease HtpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details amino acids 38 to 59 (22 residues), see Phobius details amino acids 158 to 178 (21 residues), see Phobius details amino acids 198 to 221 (24 residues), see Phobius details PF01435: Peptidase_M48" amino acids 81 to 297 (217 residues), 136.1 bits, see alignment E=6.6e-44

Best Hits

Swiss-Prot: 94% identical to HTPX_ACIAD: Protease HtpX (htpX) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 94% identity to aci:ACIAD2833)

Predicted SEED Role

"Probable protease htpX homolog (EC 3.4.24.-)" (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (301 amino acids)

>MPMX26_00808 Protease HtpX (Acinetobacter radioresistens SK82)
MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLISLFMS
KWMAKKATGTQIIDPNAPQNQAEAWLLQTVAELSQRSGIQMPEVGIFPSYQSNAFATGWN
KNDALVSVSTGLLERMNKDELRAVLAHEIGHVANGDMVTLALIQGVVNAFVMFFARVVGD
FIDRNVFGREDGEAPGLAYFAITIVLDIVFGILASAIVMWFSRYREYRADEAGAQLAGKQ
AMISALLRLQAESDMPDQMPKEMKAFAISSGKEGGFSLAALFMTHPTIEDRVAALQRLNC
P