Protein Info for MPMX26_00732 in Acinetobacter radioresistens SK82

Annotation: Glutamyl-tRNA reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 427 TIGR01035: glutamyl-tRNA reductase" amino acids 4 to 407 (404 residues), 393.8 bits, see alignment E=4.7e-122 PF05201: GlutR_N" amino acids 6 to 152 (147 residues), 171.8 bits, see alignment E=1.3e-54 PF01488: Shikimate_DH" amino acids 168 to 306 (139 residues), 133.7 bits, see alignment E=7.4e-43 PF00745: GlutR_dimer" amino acids 320 to 412 (93 residues), 53.3 bits, see alignment E=4.3e-18

Best Hits

Swiss-Prot: 79% identical to HEM1_ACIBC: Glutamyl-tRNA reductase (hemA) from Acinetobacter baumannii (strain ACICU)

KEGG orthology group: K02492, glutamyl-tRNA reductase [EC: 1.2.1.70] (inferred from 79% identity to abc:ACICU_00791)

MetaCyc: 44% identical to glutamyl-tRNA reductase (Escherichia coli K-12 substr. MG1655)
Glutamyl-tRNA reductase. [EC: 1.2.1.70]

Predicted SEED Role

"Glutamyl-tRNA reductase (EC 1.2.1.70)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 1.2.1.70)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.70

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (427 amino acids)

>MPMX26_00732 Glutamyl-tRNA reductase (Acinetobacter radioresistens SK82)
MSFFALGVNHQTASVELREQIAFNPERLNALFAEQSQHPVLNDMVVVSTCNRTEVYAMAE
HADMVLDWLAHANGLDVNQLIKHTYRYEDAQAITHLMRVASGLDSLMLGEPQILGQVKQA
LSIAKEAHMVSPALNRIFEYAFYAAKRVRSETAVGSHAVSMGYAVAQLALQVFSQPQELT
VMVVAAGEMNSLVAKHLAEMGVGKILICNRSRERAENLAQEIAHQVEVEILEFSELASNL
YRADVISSCTGSLYQVISYRDVKTALKKRRYQQMLMVDLAVPRDIEPKVASLDGVYLYGV
DDLQSVIDENLAQRRQAAVEAEIMVNQLATQLITHQKVQQAGSTIAAYREQGQHLTEYEL
RLALEHLQAGKDAAEVLQNFSHRLTQKLLHPTSILLKQAAQEEDPSYFEWLQDGLQGIFD
HQRKLKK