Protein Info for MPMX26_00574 in Acinetobacter radioresistens SK82

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 919 PF02739: 5_3_exonuc_N" amino acids 4 to 165 (162 residues), 184.5 bits, see alignment E=3.1e-58 TIGR00593: DNA polymerase I" amino acids 5 to 919 (915 residues), 969.2 bits, see alignment E=1.3e-295 PF01367: 5_3_exonuc" amino acids 166 to 259 (94 residues), 101.9 bits, see alignment E=5.8e-33 PF01612: DNA_pol_A_exo1" amino acids 325 to 511 (187 residues), 113.5 bits, see alignment E=2.5e-36 PF22619: DNA_polI_exo1" amino acids 352 to 483 (132 residues), 51.3 bits, see alignment E=2.8e-17 PF00476: DNA_pol_A" amino acids 547 to 917 (371 residues), 524.2 bits, see alignment E=5e-161

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 84% identity to aci:ACIAD3030)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (919 amino acids)

>MPMX26_00574 DNA polymerase I (Acinetobacter radioresistens SK82)
MPPFVLVDGSYFLFRAFHALPQLTTSTGLHTNAIRGAISAIQKLMRRIQPTHMAVIFDTP
EPTFRHELSPLYKGDRPSMPSELSQQIPYLHALIRALGIPLYSLPGAEADDIIGTLAKRA
EAAGHQVLISTGDKDMAQLVTDKVTLEDSFKDKPMDIQGVFEKFGVWPHQIIDYLTLMGD
ASDGIMGVPGVGAKTAAKLLNEYGSLGGILENVEHIKGRVSQSIKDNLEGITIDHQLATI
VCDLDLNISWEDLKLADPHVETLRNLYTELEFRNQLQSLDHPHNPNNTTYKQASAQATAL
PANKDIPDEHATLSSEEDRLGEATYHTVLTQTDWELLFQRMSSETRFAIDTETTSLDYRV
AEMVGFSVAFDAKDAYYVPLAHDYAGAPEQLNREQVLAQIKPILENDQVEKIGHHLKYDA
HIFANHGIELKGWFFDTMLASYVLNSVATRHGMDDVARLYLSHLTTTFEQVAGKGAKQKS
FNQIELEVASPYAAEDAHVTYRLYEVLAEKLKAHPELCNILYNIEMPVARILTGMEEDGI
RLDHGFLDQLSIEFAKTMQELEQQAMEMAGETFNIASPKQVGEVLFEKLGIKGGKKTTTG
QFSTSESILEKIEHPIAAVILEHRSLAKLKSTYTDALVKQSNNSTHRVHTSYHQALTATG
RLSSSDPNLQNIPIRGEIGRQIRKAFIAPAGRVLLAADYSQIELRLMAHFSQDDALLDAF
RHGQDVHRRTAAEVLGIALEDVTNDQRRQAKAVNFGLLYGMSEFGLIRQLGFTRQESQDY
IKQYFHRYPGIYEYMQRTRQLALEQGFVDTLFGRRLYTPDIDARNMMVRKAAERAAINAP
LQGSAADIIKLAMIAVDKILPKDQARLLLQVHDELVFEVDENIADELAPQLAEVMESVVE
ISVPLLVEVGKGCNWEEAH