Protein Info for MPMX26_00569 in Acinetobacter radioresistens SK82

Annotation: Exopolyphosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 TIGR03706: exopolyphosphatase" amino acids 11 to 306 (296 residues), 326.2 bits, see alignment E=1e-101 PF02541: Ppx-GppA" amino acids 25 to 308 (284 residues), 283.2 bits, see alignment E=2.6e-88 PF21447: Ppx-GppA_III" amino acids 314 to 487 (174 residues), 158.9 bits, see alignment E=1.2e-50

Best Hits

Swiss-Prot: 40% identical to GPPA_PHOPR: Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA) from Photobacterium profundum (strain SS9)

KEGG orthology group: K01524, exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC: 3.6.1.11 3.6.1.40] (inferred from 89% identity to acd:AOLE_16425)

Predicted SEED Role

"Exopolyphosphatase (EC 3.6.1.11)" in subsystem Phosphate metabolism (EC 3.6.1.11)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.11 or 3.6.1.40

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (506 amino acids)

>MPMX26_00569 Exopolyphosphatase (Acinetobacter radioresistens SK82)
MSDFLIDEELLAAIDMGSNSFHLAIARVDHGEVKKVASMSEKVQLAAGLDENKNLTEAAQ
QRGLACLARFVARLGSVQPTRMRIVATNALRQAKNGHEFIQKAAEILPKPIEIIAGREEA
RLIYLGVSHTIANGGRRLVVDIGGGSTELIIGEEFEPLHTESLQMGCVAYTKAYFADGSI
SVKAFDKAVVAARKELSAIANTYKTEGWDTVVGSSGTIKACRQIMVNMGLSDEQEKVTRE
GLYKLKEKLLKFKHASEIDFEGLKDDRRAVLPAGIAILYAVFEVLELDKLVYSDGALREG
VMYDLLGRFKHEDIRDRSVQALMGRYNADPKQAERVVKTAQQLFDGVAESLNLTCDDRDL
LRRAAYVHEIGLAISHGGYHRHGAYLLQHSDIPGFSQIDQNHLSRLVGFHRRKLRHEAKI
EVTRAGGEKLAYLCLLLRLAVLINHSRSDQVLPAIELSVVNDQQWQLSVSGDAKQWPLLI
ADLQDEQVQFKHWDIELNIQSEKFIN