Protein Info for MPMX26_00536 in Acinetobacter radioresistens SK82

Annotation: Cysteine synthase B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01136: cysteine synthase
  • amino acids 17 to 303 (287 residues), 407.2 bits, E=4.4e-126
• PF00291: PALP
  • amino acids 17 to 292 (276 residues), 257.3 bits, E=1e-80
• TIGR01138: cysteine synthase B
  • amino acids 18 to 303 (286 residues), 486.2 bits, E=4e-150

Best Hits

Swiss-Prot: 72% identical to CYSM_PSEAE: Cysteine synthase B (cysM) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K12339, cysteine synthase B [EC: 2.5.1.47] (inferred from 91% identity to acd:AOLE_16580)

MetaCyc: 68% identical to cysteine synthase B (Escherichia coli K-12 substr. MG1655)
Cystathionine gamma-lyase. [EC: 4.4.1.1, 4.4.1.28]; Cysteine synthase. [EC: 4.4.1.1, 4.4.1.28, 2.5.1.47]; SULFOCYS-RXN [EC: 4.4.1.1, 4.4.1.28, 2.5.1.47, 2.5.1.144]

Predicted SEED Role

"Cysteine synthase B (EC 2.5.1.47)" in subsystem Cysteine Biosynthesis (EC 2.5.1.47)

MetaCyc Pathways

• superpathway of branched chain amino acid biosynthesis (17/17 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-isoleucine biosynthesis I (from threonine) (7/7 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (8/9 steps found)
• L-methionine biosynthesis II (5/6 steps found)
• L-threonine degradation I (5/6 steps found)
• L-cysteine biosynthesis I (2/2 steps found)
• L-cysteine biosynthesis VII (from S-sulfo-L-cysteine) (3/4 steps found)
• D-serine degradation (2/3 steps found)
• L-cysteine degradation II (2/3 steps found)
• L-methionine degradation II (2/3 steps found)
• L-serine degradation (2/3 steps found)
• L-tryptophan degradation II (via pyruvate) (2/3 steps found)
• seleno-amino acid biosynthesis (plants) (3/5 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (6/10 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (3/6 steps found)
• felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (2/5 steps found)
• L-mimosine degradation (4/8 steps found)
• homocysteine and cysteine interconversion (1/4 steps found)
• superpathway of L-threonine metabolism (11/18 steps found)
• L-cysteine biosynthesis VI (reverse transsulfuration) (3/7 steps found)
• glycine betaine degradation III (3/7 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• glycine betaine degradation I (3/8 steps found)
• hydrogen sulfide biosynthesis II (mammalian) (1/6 steps found)
• superpathway of L-methionine salvage and degradation (5/16 steps found)
• hypoglycin biosynthesis (3/14 steps found)
• purine nucleobases degradation II (anaerobic) (10/24 steps found)
• superpathway of seleno-compound metabolism (6/19 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Glycine, serine and threonine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.144 or 2.5.1.47 or 4.4.1.1 or 4.4.1.28

Protein Sequence (308 amino acids)

>MPMX26_00536 Cysteine synthase B (Acinetobacter radioresistens SK82)
MTTMTPDFTADEFLLDYYVGKTPLVRLQRLASHTRATVLAKLEGNNPAGSVKDRPAYNMI
MQAERRGQIKPGDTLIEATSGNTGIALAMVAAMRGYKMKLIMPSNMSQERKDAMLAYGAE
LIEVTPQQGMEGARDLALQMEQDGKGLVLNQFGNPDNVEAHYLTTGPEIWKQTGGKITHF
VSSMGTTGTIMGVSKYLKEQNPDIQIVGLQPSEGSSIAGIRRWPEQYLPTIFDRSRIDRT
IDIPQIEAERTMRRLAREEGISAGTSSGGAVWASLQLAEENPDAVIVCIICDRGDRYLST
GLFSAEDK