Protein Info for MPMX19_06699 in Azospirillum sp. SherDot2

Annotation: Nickel/cobalt efflux system RcnA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 289 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 51 to 76 (26 residues), see Phobius details amino acids 91 to 109 (19 residues), see Phobius details amino acids 171 to 194 (24 residues), see Phobius details amino acids 205 to 229 (25 residues), see Phobius details amino acids 250 to 272 (23 residues), see Phobius details PF03824: NicO" amino acids 16 to 263 (248 residues), 117.8 bits, see alignment E=6.2e-38 PF13386: DsbD_2" amino acids 155 to 239 (85 residues), 31.3 bits, see alignment E=2e-11

Best Hits

Swiss-Prot: 60% identical to RCNA_ECO57: Nickel/cobalt efflux system RcnA (rcnA) from Escherichia coli O157:H7

KEGG orthology group: K08970, nickel/cobalt exporter (inferred from 63% identity to kpn:KPN_00423)

MetaCyc: 60% identical to Ni2+/Co2+ exporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-584; TRANS-RXN0-585

Predicted SEED Role

"Inner membrane protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (289 amino acids)

>MPMX19_06699 Nickel/cobalt efflux system RcnA (Azospirillum sp. SherDot2)
MPDFAALLQQGAGQAWLFVPSAILLGALHGLEPGHSKTMMAAFIVAIRGTVLQAVLLGLA
ATVSHTLVVWVVALAGLQLGQGWDAATTEPYFQVASAVLIVGVALWMMARTWREQHSHHH
HDGHHHDHEHDHDRGHHHGHHQHDDEPEDAHARTHAEEIRRRFDGRPVTTGQIVLFGLTG
GLIPCPAAITVLLLCLQLKEVALGGVLVLCFSIGLALTLMSAGVVAALGMRHAERRWSGA
FGRIARQAPYVSGALILAVGLYVGLHGLSGLGYHLAGSPSVSSAVQRAG