Protein Info for MPMX19_05795 in Azospirillum sp. SherDot2

Annotation: 2-dehydro-3-deoxygluconokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 7 to 301 (295 residues), 200.3 bits, E=2.4e-63

Best Hits

Swiss-Prot: 52% identical to KDGK_DICD3: 2-dehydro-3-deoxygluconokinase (kdgK) from Dickeya dadantii (strain 3937)

KEGG orthology group: K00874, 2-dehydro-3-deoxygluconokinase [EC: 2.7.1.45] (inferred from 94% identity to azl:AZL_d01340)

MetaCyc: 52% identical to 2-dehydro-3-deoxy-D-gluconate kinase (Dickeya dadantii 3937)
2-dehydro-3-deoxygluconokinase. [EC: 2.7.1.178, 2.7.1.45]

Predicted SEED Role

"2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)" in subsystem D-Galacturonate and D-Glucuronate Utilization or D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway (EC 2.7.1.45)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (5/5 steps found)
• D-galacturonate degradation I (5/5 steps found)
• D-fructuronate degradation (4/4 steps found)
• superpathway of β-D-glucuronosides degradation (6/7 steps found)
• D-galactonate degradation (3/3 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• L-glucose degradation (3/7 steps found)
• alginate degradation (2/7 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.178 or 2.7.1.45

Protein Sequence (306 amino acids)

>MPMX19_05795 2-dehydro-3-deoxygluconokinase (Azospirillum sp. SherDot2)
MTDTPNRVAALGECMIEMFRRPDGSLTMGFGGDTLNTAVYLARLGTPVDYVTALGDDSIS
DDMVAAWAAEGVGTGHVLRVPNRLPGLYLIETDASGERRFLYWRDRAPARELFALPQTPE
LSKALEGYGIVYLSGISIAILGEQGRERLFEVLERVRARGGKVAFDTNWRPRLWPDLDTA
RAAFDRMLALTDIALPGVTDLRDLYGDADADAVLARVRKAGVTEIVLKLEQPGCVVIENG
EAVEVPAQKVATVVDTTAAGDSFSAGYLAARLRGEGPADAARAAHKLAAAVIQHRGAIIP
RDAMPA