Protein Info for MPMX19_05793 in Azospirillum sp. SherDot2

Annotation: Galactarate dehydratase (L-threo-forming)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 12 to 79 (68 residues), 28.8 bits, E=2.2e-10
• PF04295: GD_AH_second
  • amino acids 112 to 254 (143 residues), 149.2 bits, E=1.2e-47
• PF20629: GD_AH_C
  • amino acids 263 to 505 (243 residues), 348.7 bits, E=2.3e-108

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 96% identity to azl:AZL_d01360)

MetaCyc: 66% identical to D-arabinonate dehydratase (Herbaspirillum huttiense)
Arabinonate dehydratase. [EC: 4.2.1.5]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• D-galacturonate degradation I (5/5 steps found)
• D-arabinose degradation III (3/6 steps found)
• D-arabinose degradation IV (2/6 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)
• superpathway of pentose and pentitol degradation (14/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.7

Use Curated BLAST to search for 4.2.1.5 or 4.2.1.7

Protein Sequence (507 amino acids)

>MPMX19_05793 Galactarate dehydratase (L-threo-forming) (Azospirillum sp. SherDot2)
MASLTIRLHPADNVVVAGADLESGILLPATEVATTGPVPAGHKVAVRAIAPGEPVRKYNQ
VIGFATAAIQPGDHVHVHNMGMGSDFERDYAFGADVHPVEPIPEAERATFQGIVRPDGRV
ATRNYIGVLTSVNCSATAARMIADHFRGSALAAYPNIDGVVALTHGYGCGMAGSGEVMDT
LRRTIAGYARHPNFAAVILLGLGCEVNQIDKLMEATGLEEGARVIPIGIQDMGGTAAAAR
EGIRRIEALLPEINDVTRQTLPASHLTLALQCGGSDGYSGITANPALGYAVDLLVRNGGT
AVLSETPEVYGAEHLLTRRAVRREVGEALVERIGWWEEYTSRTGGEMNNNPSPGNKKGGL
TTILEKSLGAVAKGGTTPMTAVYRYAEPITDKGFVFMDTPGYDPVSATGQVAGGANVLCF
TTGRGSVFGCKPTPSLKLATNSTLFRRMPDDMDIDCGAIATGDATIEEVGRAIFQLVLDT
ASGRKTKSEELGVGADEFAPWQMGAVM