Protein Info for MPMX19_05657 in Azospirillum sp. SherDot2

Annotation: Succinyl-CoA:coenzyme A transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03458: succinate CoA transferase
  • amino acids 14 to 494 (481 residues), 745.6 bits, E=1.1e-228
• PF02550: AcetylCoA_hydro
  • amino acids 14 to 215 (202 residues), 102 bits, E=6.8e-33
• PF13336: AcetylCoA_hyd_C
  • amino acids 331 to 458 (128 residues), 130.9 bits, E=6e-42
• PF04223: CitF
  • amino acids 340 to 433 (94 residues), 27.1 bits, E=3.2e-10

Best Hits

Swiss-Prot: 51% identical to CAT1_CLOK5: Succinyl-CoA:coenzyme A transferase (cat1) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)

KEGG orthology group: K01067, acetyl-CoA hydrolase [EC: 3.1.2.1] (inferred from 96% identity to azl:AZL_d02810)

MetaCyc: 51% identical to succinyl-CoA:CoA transferase (Clostridium kluyveri)
RXN-8807 [EC: 2.8.3.18]

Predicted SEED Role

"Acetyl-CoA hydrolase"

MetaCyc Pathways

• pyruvate fermentation to acetate V (3/3 steps found)
• pyruvate fermentation to acetate VI (3/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (13/17 steps found)
• TCA cycle VII (acetate-producers) (7/9 steps found)
• acetate formation from acetyl-CoA (succinate) (1/1 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• succinate fermentation to butanoate (2/7 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.8.3.18 or 3.1.2.1

Protein Sequence (502 amino acids)

>MPMX19_05657 Succinyl-CoA:coenzyme A transferase (Azospirillum sp. SherDot2)
MYRDRIRLKSLWGKVVPAEEAAFLIKDGMTVGMSGFTRAGDAKAVPLALAERAASEKLKI
TLMTGASLGNDVDRILTEAGVLSRRLPFQADPVLRKAINRGEVMFVDQHLSETVELLRSR
QMGPVDVAVIEACAITDTGGIVPTTSIGNSATFAILAEKIIIELNLTQPLDLEGMHDVYI
PTRRPFREPIPVVTAESRAGLPYIPIDPSKIAAIVVTRKQDSSASILPPDDETNAIAGHL
IEFFGREVKQGRLGRSLAPLQAGIGTIANAVLHGLIDGPFHDLTMYSEVLQDSTFELFDA
GKLTFASGSSITLSAGKYAEVLPKIGSYKGRLLLRPQEISNHPEVIRRLGVIGINTALEC
DIYGNVNSTHVNGTQMMNGIGGSGDFARNSHLAIFVTKSLAKGGAISSIVPMVTHVDHNE
HDVDVLVTEIGLADLRGLAPRERAETIIRNCVHPSYRELAADYHRRALQRGGHTPHLLEE
AFAWHSRFQQTGSMMPAALAAD