Protein Info for MPMX19_05333 in Azospirillum sp. SherDot2

Annotation: Thymidine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 transmembrane" amino acids 127 to 147 (21 residues), see Phobius details TIGR02645: putative thymidine phosphorylase" amino acids 2 to 495 (494 residues), 619.2 bits, see alignment E=2.2e-190 PF02885: Glycos_trans_3N" amino acids 94 to 154 (61 residues), 41.7 bits, see alignment E=1.2e-14 PF00591: Glycos_transf_3" amino acids 164 to 392 (229 residues), 41.7 bits, see alignment E=1.6e-14 PF07831: PYNP_C" amino acids 426 to 485 (60 residues), 43.7 bits, see alignment E=2.7e-15

Best Hits

Swiss-Prot: 60% identical to TYPH_RHOPA: Putative thymidine phosphorylase (RPA4147) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K00758, thymidine phosphorylase [EC: 2.4.2.4] (inferred from 60% identity to rpt:Rpal_4625)

Predicted SEED Role

"Thymidine phosphorylase (EC 2.4.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 2.4.2.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.4

Use Curated BLAST to search for 2.4.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (496 amino acids)

>MPMX19_05333 Thymidine phosphorylase (Azospirillum sp. SherDot2)
MLTLRHLAIDTVRENVAFLNRRCTRYHVEDFLGLGRVEVRNDGRSLLAVLNVVDDPAIVA
PDEIGLSDPAFGQLGLAAGSAVHLVPPTPPESFELVRAKVGGAALTDAQLSAIIRDITDQ
RYSKIEIAAFLIACASFMTTAEVLGLTRAMIAAGTRLHWQDLGTIADKHCIGGIPGNRTS
MIVVPIVAAHGLPIPKTSSRAITSPAGTADTMEVLANVDVPMERMQALVREAKGCLVWGG
HVRLSPADDILISVERPLAIDTREQLVASILSKKVAAGSSHLLIDIPVGPSAKIRTAGEA
VRLRKLFEHVGDRLGLTLEVAITDGSQPVGRGIGPVLEARDVMAVLRNEPAGPADLRERA
LLLAGRILEFDPAVRGGSGNRRARELLRSGAALAAMERIIALQGPPPAVATLGSLVAEVA
SPADGIVSSLDCYRLARIARLAGAPTDKGAGIDLLRKVGEPVRRGEPLYRIHASTNADFT
FAQAFAAENSGVAVVG