Protein Info for MPMX19_04920 in Azospirillum sp. SherDot2

Annotation: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 20 to 479 (460 residues), 580.7 bits, E=9.4e-179
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 31 to 478 (448 residues), 738.8 bits, E=1.1e-226

Best Hits

Swiss-Prot: 67% identical to GABD_ECOLI: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (gabD) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 96% identity to azl:AZL_c00270)

MetaCyc: 67% identical to succinate-semialdehyde dehydrogenase (NADP+) GabD (Escherichia coli K-12 substr. MG1655)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.79, 1.2.1.20]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• 4-hydroxyphenylacetate degradation (6/8 steps found)
• methylglyoxal degradation V (2/3 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• lactate biosynthesis (archaea) (3/5 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-rhamnose degradation II (4/8 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• L-lysine degradation I (3/7 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of fucose and rhamnose degradation (4/12 steps found)
• nicotine degradation II (pyrrolidine pathway) (3/11 steps found)
• nicotine degradation I (pyridine pathway) (7/17 steps found)
• superpathway of L-lysine degradation (13/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.22 or 1.2.1.79

Protein Sequence (486 amino acids)

>MPMX19_04920 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (Azospirillum sp. SherDot2)
MLSLNDQGLLRTKGYVNGAWRAADSGKSFPVTNPATGAVIAEVSDMGAAETREAIDAANA
ALPGWKAKTAKERAAIMRRWYELIIAAQEDLAQLMTAEQGKPLTESRGEVVYGASFIEWF
AEEGKRAYGDVIPSFAANKRIVVLKEAIGVVAAITPWNFPNAMITRKVAPALAAGCTVVV
KPAEDTPLSALALAELAERAGFPAGVFNIVMGSEPAAIGNELTHSPIVRKVSFTGSTEVG
KLLMRQAASTVKKVSLELGGNAPFIVFDDADLDEAVKGAMASKYRNAGQTCVCANRLLVQ
AGVYDAFAAKLAEAVKALKVGDGTEAGVTQGPLINADAIAKVEELMGDALEKGATVALGG
KRHALGGTFFEPTILTGITTEMRVAREEIFGPVAPLFKFETEEDAIRMANDTEFGLAAYF
YSRDIGRVWRVAEKLEYGIVGINEGIISTEVAPFGGVKESGIGREGSKYGLDDFMEVKYL
CVGLGA