Protein Info for MPMX19_04814 in Azospirillum sp. SherDot2
Annotation: ATP phosphoribosyltransferase regulatory subunit
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 62% identical to HISZ_RHOCS: ATP phosphoribosyltransferase regulatory subunit (hisZ) from Rhodospirillum centenum (strain ATCC 51521 / SW)
KEGG orthology group: K02502, ATP phosphoribosyltransferase regulatory subunit (inferred from 96% identity to azl:AZL_c04100)Predicted SEED Role
"ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
- L-histidine biosynthesis (10/10 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Histidine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.17
Use Curated BLAST to search for 2.4.2.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (384 amino acids)
>MPMX19_04814 ATP phosphoribosyltransferase regulatory subunit (Azospirillum sp. SherDot2) MPADALSSALLPAGLHDVLPSEAAHEAAAVERLLAEFAAQGYRRVDPPLVEFEENLLSGP GAAMSKQTFRLMDPHSQRMMAVRADITPQIARIATTRLKNEARPLRLCYAGQVLRVKGSQ LRPERQFTQVGVELIGALEAEADAEVVLLAVQALTAIGVPHLSVDLCVPTMVSRICAGLG LGEDEIRQLRAALDRKDSAAVAAVGGPAASLLETLMSASGPADRAMQALAALPLPEGAEK DRRRLTDTLALLRAAMPDLTVTIDLVEHRGFEYQTGLSFTLFSRAAGELGQGGRYRAGAQ GEDRGEPATGFTLYMDTLLRAVPAAKAPGRVYVPHGSGWETARRLRADGWVTVAGLAPVA DAAAEARRLHCGHWLAGGDVKPVG