Protein Info for MPMX19_04557 in Azospirillum sp. SherDot2

Annotation: Na(+)/H(+) antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 55 to 78 (24 residues), see Phobius details amino acids 98 to 117 (20 residues), see Phobius details amino acids 129 to 148 (20 residues), see Phobius details amino acids 157 to 178 (22 residues), see Phobius details amino acids 184 to 201 (18 residues), see Phobius details amino acids 209 to 240 (32 residues), see Phobius details amino acids 263 to 286 (24 residues), see Phobius details amino acids 297 to 320 (24 residues), see Phobius details amino acids 336 to 358 (23 residues), see Phobius details amino acids 370 to 390 (21 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 18 to 387 (370 residues), 470.3 bits, see alignment E=2.2e-145 TIGR00773: Na+/H+ antiporter NhaA" amino acids 19 to 387 (369 residues), 443.1 bits, see alignment E=4e-137

Best Hits

Swiss-Prot: 68% identical to NHAA_MAGSA: Na(+)/H(+) antiporter NhaA (nhaA) from Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 68% identity to mci:Mesci_0199)

MetaCyc: 56% identical to Na+:H+ antiporter NhaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-129; TRANS-RXN-292

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (401 amino acids)

>MPMX19_04557 Na(+)/H(+) antiporter NhaA (Azospirillum sp. SherDot2)
MTNRKADSRNRPLSVFREFLESEASGGLLLMGAAAAALAVANSPLSDIYFRSLHAYFLGL
SVGHWINDGLMAVFFLLVGLEIKREMLDGQLSTWPRRILPGLAAAGGMLFPALIYTAFNR
GNPDTMSGWAIPTATDIAFALGVLSLLGPRVPTSLKIFLTALAIIDDLGAVLIIALFYTA
DLSLPALGGAAAILTALVLLNRSGVERLWLYLILGVGLWGAVLLSGIHATLAGVVLALTI
PLRPAPGRPDDMQSPLHRLEHGIHGWVAFLIVPLFGFANAGVSFAGMDGSILTGSLPLGI
AFGLFAGKMVGVFGTAWITVRLGFADMPAGASTTQLFGVALLCGIGFTMSLFIGALAFPT
APELGDAVKVGVFAGSLLSATAGALLLRYAQPEKRPVPGHS