Protein Info for MPMX19_04465 in Azospirillum sp. SherDot2

Annotation: Pantothenate synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 PF02569: Pantoate_ligase" amino acids 23 to 296 (274 residues), 329 bits, see alignment E=9.8e-103 TIGR00018: pantoate--beta-alanine ligase" amino acids 23 to 297 (275 residues), 285.2 bits, see alignment E=4.2e-89 TIGR00125: cytidyltransferase-like domain" amino acids 44 to 95 (52 residues), 30.7 bits, see alignment 2.8e-11

Best Hits

Swiss-Prot: 64% identical to PANC_MAGSA: Pantothenate synthetase (panC) from Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)

KEGG orthology group: K01918, pantoate--beta-alanine ligase [EC: 6.3.2.1] (inferred from 92% identity to azl:AZL_a03250)

MetaCyc: 45% identical to pantothenate synthetase (Escherichia coli K-12 substr. MG1655)
Pantoate--beta-alanine ligase. [EC: 6.3.2.1]

Predicted SEED Role

"Pantoate--beta-alanine ligase (EC 6.3.2.1)" in subsystem Coenzyme A Biosynthesis (EC 6.3.2.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (302 amino acids)

>MPMX19_04465 Pantothenate synthetase (Azospirillum sp. SherDot2)
MTPTPAPSSSNPIGTLSAGTLPILQTVEDLRSQVAAWRRERLTVALVPTMGALHDGHLGL
IRRGRELADRVVASVFVNPTQFAPHEDFDRYPRDESGDAAKLASAGCHTLYAPTVPAMYP
QGFATAISVGGPAEGLCGTFRPQMFGGVALVVTKLFLQALPDVAVFGEKDYQQLMVIRRF
THDLDIPVRVEGLPTVREADGLAMSSRNAYLSADERARAPELNRALTAAAAALAAGAEVD
GVLTGIRGRIAEAGFGAIDYVELRDAETLEPVSAVTRPARLLAAAWMGKARLIDNVPVIP
AG