Protein Info for MPMX19_04115 in Azospirillum sp. SherDot2

Annotation: Sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 749 PF01627: Hpt" amino acids 7 to 97 (91 residues), 49.6 bits, see alignment E=7.9e-17 PF02518: HATPase_c" amino acids 332 to 474 (143 residues), 56 bits, see alignment E=1e-18 PF01584: CheW" amino acids 480 to 608 (129 residues), 45.2 bits, see alignment E=1.5e-15 PF00072: Response_reg" amino acids 632 to 745 (114 residues), 81.8 bits, see alignment E=8.1e-27

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 84% identity to azl:AZL_a03120)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (749 amino acids)

>MPMX19_04115 Sensor histidine kinase RcsC (Azospirillum sp. SherDot2)
MDIRQRLLAAFDLEHKDHLAAIRNALRDAEATGDAPDLVDIHRRAHSLKGAARAVDLPEV
EAISHRLEAAFIAVQKGEIPLDPASVGVVRRSLDAIEDLVAWSLQGGDPVETAGVLADLD
ALAAGRSGGSVPAPSPAAARAAVRRPPAQRDRAADADSAALVRIAAQGLERLSETASALL
PEVEAQAGLGEQLRTMRREWRALDRAWRHLRVQIGRGVRADAGAGADALPSALDGRGALP
ALMAFERRFRALGGALDSAHRSHDRLLWSMRRWGGGLQQDMRRLRMLPAENQLSGLGRMV
RDISRAEGKEVEVDVRGLEVEADRTVLQRLKDPILHIARNAISHGIETPAERLALGKRPA
ARVTIAASVEGARLRLRIEDDGRGLDRAAILRKAAERGLIDAADLSTGAEMPQERLTEFL
FHPGFSTAAQTTELAGRGMGLAIARREVERLQGNLTIADRADGGTAVTIEVPLSLLSQRL
VFVLVQDQTLAIPSADVVRLRTASAQSLFSGTGTPMTRIGDEEIPVTSLAALLGMEAPVV
PSAERGLSLVVVRAGDRRLALAVDRFVATRETVVTAAEETGLDSGRYLGTVLMDDGGPAL
VLNIPGLMPLPGSTLPAPARPAEEATPARAHILVVDDSITTRTLEKSILEAHGYRVTLCV
DGREALERLSEGMEVGLIISDVEMPRMDGFALLQAVKADKRLEEIPVILVTSRASDEDRE
RGLRLGADAYIVKTRFDQNELLAGIRRLL