Protein Info for MPMX19_04055 in Azospirillum sp. SherDot2
Annotation: 2,5-diketo-D-gluconic acid reductase B
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 43% identical to DKGB_YERPE: 2,5-diketo-D-gluconic acid reductase B (dkgB) from Yersinia pestis
KEGG orthology group: None (inferred from 76% identity to mes:Meso_3052)MetaCyc: 43% identical to methylglyoxal reductase DkgB (Escherichia coli K-12 substr. MG1655)
Aryl-alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.91]; RXN0-7020 [EC: 1.1.1.91, 1.1.1.346]; Aldehyde reductase. [EC: 1.1.1.91, 1.1.1.346, 1.1.1.21]
Predicted SEED Role
No annotation
MetaCyc Pathways
- methylglyoxal degradation III (1/2 steps found)
- L-ascorbate biosynthesis VIII (engineered pathway) (4/7 steps found)
- D-arabinose degradation V (1/3 steps found)
- D-galactose degradation IV (1/3 steps found)
- ketogluconate metabolism (4/8 steps found)
- superpathway of methylglyoxal degradation (4/8 steps found)
- detoxification of reactive carbonyls in chloroplasts (1/10 steps found)
- superpathway of pentose and pentitol degradation (14/42 steps found)
KEGG Metabolic Maps
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Pentose and glucuronate interconversions
- Pyruvate metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.21 or 1.1.1.346 or 1.1.1.91
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (274 amino acids)
>MPMX19_04055 2,5-diketo-D-gluconic acid reductase B (Azospirillum sp. SherDot2) MQTVKANGAEIPALGFGVFRMSDEEVERVVPAALEAGFRHFDTAQIYRNEAALGRALQAA GARRDELFLTTKVWVDKYSPDLFAASVDESLEKLKVDNIDLLLLHWPADQVAIAEQIEML NAVQAAGKTRFIGVSNQNIAQLRESVERSQAPIVTNQIEVHPYLDQSAMAAAASELGVAI TAYYAMADGKVPRDPELQRIGAKHGKTAAQVTLRWLIQLGHIVLSKTAKPERVPENFAVF DFALDDGDMAAIATLAQPNGRIVSPAGLAPAWDK