Protein Info for MPMX19_04043 in Azospirillum sp. SherDot2
Annotation: Aldehyde-alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 73% identical to ADHE_ECO57: Aldehyde-alcohol dehydrogenase (adhE) from Escherichia coli O157:H7
KEGG orthology group: K04072, acetaldehyde dehydrogenase / alcohol dehydrogenase [EC: 1.1.1.1 1.2.1.10] (inferred from 95% identity to azl:AZL_a08020)MetaCyc: 73% identical to fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE (Escherichia coli K-12 substr. MG1655)
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]; Alcohol dehydrogenase. [EC: 1.2.1.10, 1.1.1.1]; 1.1.1.1 [EC: 1.2.1.10, 1.1.1.1]
Predicted SEED Role
"Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)" (EC 1.1.1.1, EC 1.2.1.10)
MetaCyc Pathways
- mixed acid fermentation (14/16 steps found)
- hexitol fermentation to lactate, formate, ethanol and acetate (16/19 steps found)
- superpathway of anaerobic sucrose degradation (16/19 steps found)
- heterolactic fermentation (15/18 steps found)
- superpathway of L-threonine metabolism (15/18 steps found)
- ethanolamine utilization (5/5 steps found)
- superpathway of N-acetylneuraminate degradation (17/22 steps found)
- 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
- superpathway of purine deoxyribonucleosides degradation (6/7 steps found)
- 2-aminoethylphosphonate degradation I (3/3 steps found)
- 2-deoxy-D-ribose degradation I (3/3 steps found)
- ethanol degradation II (3/3 steps found)
- pyruvate fermentation to ethanol I (3/3 steps found)
- pyruvate fermentation to ethanol III (3/3 steps found)
- superpathway of pyrimidine deoxyribonucleosides degradation (5/6 steps found)
- L-threonine degradation IV (2/2 steps found)
- ethanol degradation I (2/2 steps found)
- superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
- acetylene degradation (anaerobic) (4/5 steps found)
- pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
- acetaldehyde biosynthesis I (1/1 steps found)
- L-phenylalanine degradation III (3/4 steps found)
- phytol degradation (3/4 steps found)
- 2-deoxy-α-D-ribose 1-phosphate degradation (2/3 steps found)
- 2-hydroxypenta-2,4-dienoate degradation (2/3 steps found)
- L-isoleucine degradation II (2/3 steps found)
- L-leucine degradation III (2/3 steps found)
- L-valine degradation II (2/3 steps found)
- pyruvate fermentation to ethanol II (1/2 steps found)
- (S)-propane-1,2-diol degradation (3/5 steps found)
- L-tyrosine degradation III (2/4 steps found)
- L-methionine degradation III (1/3 steps found)
- sulfoacetaldehyde degradation IV (1/3 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (8/13 steps found)
- catechol degradation I (meta-cleavage pathway) (2/5 steps found)
- salidroside biosynthesis (1/4 steps found)
- catechol degradation II (meta-cleavage pathway) (3/7 steps found)
- serotonin degradation (3/7 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (10/17 steps found)
- phenylethanol biosynthesis (1/5 steps found)
- butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
- toluene degradation I (aerobic) (via o-cresol) (2/7 steps found)
- toluene degradation V (aerobic) (via toluene-cis-diol) (2/7 steps found)
- meta cleavage pathway of aromatic compounds (4/10 steps found)
- triethylamine degradation (1/6 steps found)
- L-tryptophan degradation IX (5/12 steps found)
- L-tryptophan degradation XII (Geobacillus) (5/12 steps found)
- 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (2/8 steps found)
- p-cumate degradation (2/8 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- toluene degradation IV (aerobic) (via catechol) (4/13 steps found)
- naphthalene degradation to acetyl-CoA (3/12 steps found)
- p-cymene degradation (2/11 steps found)
- mandelate degradation to acetyl-CoA (7/18 steps found)
- L-tryptophan degradation V (side chain pathway) (1/13 steps found)
- superpathway of aerobic toluene degradation (11/30 steps found)
- superpathway of aromatic compound degradation via 3-oxoadipate (14/35 steps found)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate (10/42 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Butanoate metabolism
- Drug metabolism - cytochrome P450
- Fatty acid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Metabolism of xenobiotics by cytochrome P450
- Pyruvate metabolism
- Retinol metabolism
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.1, 1.2.1.10
Use Curated BLAST to search for 1.1.1.1 or 1.2.1.10
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (894 amino acids)
>MPMX19_04043 Aldehyde-alcohol dehydrogenase (Azospirillum sp. SherDot2) MVTTVKTLSDLNALIARVKAAQARFADYPQEKVDLIFRSAALAAANARIPLAKMAVAETG MGVMEDKVIKNHFAAEYIYNKYKDDKTCGVLSEDNDAGILTIAEPVGLICGIVPTTNPTS TAIFKALIALKTRNGLVLSPHPRARKSTCEAARLVLAAAVEAGAPDDIIGWIDEPSLELS NAVMHHPDIALILATGGPGMVKAAYSSGKPAIGVGAGNTPAVIDEFADIKRAVASILMSK TFDNGVVCASEQSAVVVEAVYDAVRDRFAHHGGYILSPREADAVRKILLTDGHLNADIVG QPAHAIAAMAGLNVPLATKVLIAEVSDVDDSEPFAHEKLSPTLALYRAKDFTEACDKAAA LVALGGIGHTSALYTDQDRQAGRIRHFGDKMKTARILINTPSSHGGIGDLYNFRLAPSLT LGCGSWGGNSISENVGPQHLINKKTVAKRAENMLWHKLPKSIYFRRGCLPFALEELRGKK RCLIVTDRFLFENGHVNDSVRVLKSLGLEVETFFEVSADPTLAVVRKGVALANAFQPDVI LALGGGSPMDAAKIIWVMYEAPEVAFEDLALRFMDIRKRIYTFPKLGVKAQLVAVPTTSG TGSEVTPFAVVTDERTGTKYPIADYELTPSMAIVDANLVMDMPKGLTAAGGIDAVTHALE AYVSVVANEYSDGQALQALKLLKEHLPSAYRNGGQDPKARELVHNAATLAGIAFANAFLG VCHSMAHKLGAEFHIPHGIANALLIANVIRYNAADIPTKQTAFSQYDRPKGVARYAQIAR HLELGGSRDHERVEKLIAWVEELKRALEIPASIQAAGVPEAAFLARVDAIAEAAFDDQCT GANPRYPLVAEIRQLLIDSYYGRAYVEPSAQDAAPVEVKPAGKSAARKDAAFAK