Protein Info for MPMX19_03748 in Azospirillum sp. SherDot2

Annotation: Sensor protein KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 921 transmembrane" amino acids 407 to 427 (21 residues), see Phobius details amino acids 437 to 473 (37 residues), see Phobius details amino acids 487 to 507 (21 residues), see Phobius details PF02702: KdpD" amino acids 31 to 239 (209 residues), 328.3 bits, see alignment E=5.3e-102 PF00582: Usp" amino acids 261 to 375 (115 residues), 25.2 bits, see alignment E=6.2e-09 PF13493: DUF4118" amino acids 411 to 516 (106 residues), 102.3 bits, see alignment E=3.6e-33 PF13492: GAF_3" amino acids 537 to 667 (131 residues), 48.2 bits, see alignment E=4.2e-16 PF00512: HisKA" amino acids 687 to 754 (68 residues), 54.7 bits, see alignment 2.5e-18 PF02518: HATPase_c" amino acids 799 to 909 (111 residues), 96.1 bits, see alignment E=5.6e-31

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 65% identity to msl:Msil_2823)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (921 amino acids)

>MPMX19_03748 Sensor protein KdpD (Azospirillum sp. SherDot2)
MTDEQSERIQGDRAGRPSPDALLRQAAKEAQGRLKIFLGAAPGVGKTFEMLQTAQAKRRD
GVDIVVGVVETHGRRETEALVAGLEVVPRRAIEHKGHVLTEMDVDAILARRPKIVLVDEL
AHTNADGGRHPKRYLDVEELLAAGIDVYTTLNIQHVESLNDVVAKITRVRVRETVPDSIL
DRADDIEVIDIAPDDLIQRLQQGKVYVPRTAERAIRHYFSPGNLTALRELALRRTADRVD
EQLLTHMQAHAISGPWAAGERLLVCINEDASGGALVRYARRQAERLRARWGAIHVETSRA
LRLSEADRDRIADTLRLVERLGGEAVTLPGSDVADTVVDYALTNNVTHIVIAKSTRPRWS
ELLHGSVAHSLIRRAGDISVHVIAAGSGAALPARTVRTEAARQRAFAWWPYVASTGYVAA
ALGAGHVLHRVLALNNMALVFLTAVLASAVTGGLAPSLYASVISVLAFNYFFLPPLYTFT
ISDPENIVALLVFAVVSVIASNLTARVRAQAVTARLRAKTTEDLYQFSRKLAGVVTMDDL
LWATAYQIAAMLKVHVVLLLPESGPGEGHGKGSVAVRAGYPPEDVIEDADLAAAVWAWEN
NRPTGKGADTLPGAKWLFLPMRTGRGVVGVVGIDTGGGKGRTGGYLTPDERRLLDALIDQ
AALAIERVTLAEDVDRSKLAAETERLRSALLTSISHDLRTPLASILGSATSLVGYGPMMD
EEDRRDLAATIQEEAERLNRFIANLLDMTRLESGAIRPRTGAVDLSEVVGSALERVSRIL
AGHRVEVDLAAGLPMVDIDAVLIEQALFNLLDNAGKYAPAGSTITVRGRQDGALVRIEVL
DEGGGIPPEDVERIFDKFYRVHAQDRQRAGTGLGLAICRGFVEAMGGTVTAGNRRDRSGA
VFTLTLPKAADMSGYEEEAAA