Protein Info for MPMX19_03090 in Azospirillum sp. SherDot2

Annotation: Macrolide export ATP-binding/permease protein MacB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 643 transmembrane" amino acids 271 to 292 (22 residues), see Phobius details amino acids 299 to 316 (18 residues), see Phobius details amino acids 520 to 545 (26 residues), see Phobius details amino acids 573 to 598 (26 residues), see Phobius details amino acids 603 to 626 (24 residues), see Phobius details PF00005: ABC_tran" amino acids 26 to 174 (149 residues), 122.2 bits, see alignment E=3.9e-39 PF12704: MacB_PCD" amino acids 271 to 488 (218 residues), 154.2 bits, see alignment E=8.9e-49 PF02687: FtsX" amino acids 524 to 636 (113 residues), 64.6 bits, see alignment E=1.3e-21

Best Hits

Swiss-Prot: 52% identical to MACB_NITWN: Macrolide export ATP-binding/permease protein MacB (macB) from Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)

Predicted SEED Role

"Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-)" in subsystem Multidrug Resistance Efflux Pumps (EC 3.6.3.-)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (643 amino acids)

>MPMX19_03090 Macrolide export ATP-binding/permease protein MacB (Azospirillum sp. SherDot2)
MSAPLLVLEDIRKTYATGGGVAVEVLRGVSLTVGAGEFVAIVGSSGSGKSTLMNILGGLD
RPTSGSYRVNGRDVSELEGDERAALRRDGFGFVFQHYHLIPGTSALENVEMPGRYAGLPA
AVRESRAAALLGRLGLAERRHHRPNQLSGGQQQRVSIARALMNGAPVILADEPTGALDSA
SGAEVVALLRELAAEGRTIVLITHDRKVAEAADRVVEMRDGRIVSDSGRRASTAAPAPAP
AERHTPASVWTSAGEAFTAALRSLGANGFRTALTLLGIVIGVASVIALLAIGEGAKRAVM
ARVGALGVNLVYVLAGSGDPRLPTTPLTEADGEAILRLPNVESVMPYLDMPVMVRYRNID
HRTSGLATSASLPLTHRWPVALGSFFTAADERAGAAVAVLGHNVAKRLFPNGESPLGRHV
QVNNIPFQVTGVMGQKGDLTGSQDTDDWVFVPLSTGVQRLVGKPDLQLILVSVHTVGRIA
ETRDAIKALMTKRHGQEDFQIRDVTARIRTATETQDTMTLLLGSAAVVTLLVGGIGVMNI
MLVSVTERTREIGIRMAAGARAADIERQFLMEAALVAGLGGLVGVALGLASGALVGLFVM
PVLFTATAIAGAVTSAVVTGLVFGLIPARRAARLDPVAALSSE