Protein Info for MPMX19_01943 in Azospirillum sp. SherDot2

Annotation: Gamma-glutamyl phosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 8 to 287 (280 residues), 70.5 bits, E=5.3e-24
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 22 to 413 (392 residues), 457.1 bits, E=2.4e-141

Best Hits

Swiss-Prot: 65% identical to PROA_MAGSA: Gamma-glutamyl phosphate reductase (proA) from Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 95% identity to azl:AZL_023380)

MetaCyc: 44% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-citrulline biosynthesis (7/8 steps found)
• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• superpathway of L-citrulline metabolism (9/12 steps found)
• L-N^δ-acetylornithine biosynthesis (5/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (424 amino acids)

>MPMX19_01943 Gamma-glutamyl phosphate reductase (Azospirillum sp. SherDot2)
MSALLDTADALHDQMIALGRAARAAAAALATVPGPSKDRALRAAAAAIRARAAEIKAANA
EDMANARDLSGPMRERLMLDDTRIEAMAKGLEDIADFPDPIGGVLAEWTRPNGLRIQRVR
VPLGVVGIIYESRPNVTADAGGICLKSGNAAILRGGSESIRSSRAIASCLAQGLREAGLP
EAAIQLVPTTDRAAVGHMLTMRDYIDVIIPRGGKSLIQRIADESRVPVIKHLDGNCHVYV
DAAADLEKARKVVLNAKMRRTSICGAAETLLVDRAIADKALPVLVKDLLDAGCAVRGDAA
AQAVDPRVTAVVPEDWDTEYLDAIIACGVVDGVDGAIDHIDAHSSHHTESILTEDPSVAE
RFLSRVDSGIVLWNASTQFADGGEFGMGAEIGISTDKFHARGPVGAEQLTSYKYVVRGDG
QTRP