Protein Info for MPMX19_01633 in Azospirillum sp. SherDot2

Annotation: Dihydroorotase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00856: dihydroorotase, homodimeric type
  • amino acids 6 to 347 (342 residues), 447 bits, E=1.9e-138
• PF01979: Amidohydro_1
  • amino acids 13 to 306 (294 residues), 61.2 bits, E=5.4e-21

Best Hits

Swiss-Prot: 64% identical to PYRC_NOVAD: Dihydroorotase (pyrC) from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 93% identity to azl:AZL_019880)

MetaCyc: 59% identical to dihydroorotase (Escherichia coli K-12 substr. MG1655)
Dihydroorotase. [EC: 3.5.2.3]

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (351 amino acids)

>MPMX19_01633 Dihydroorotase (Azospirillum sp. SherDot2)
MPNDRLVIRRPDDWHVHLRDGAMLKAVLPFTARQFGRAIVMPNLKPPVATAADAVAYRER
ILAALPDGVAFTPLMTAYLTDGTDADDLAEGFKDGVFAAAKLYPANATTNSAHGVTDIAR
IAPVLERMADIGMPLLIHGEVTDQSVDIFDREAVFIDSILAPLLERHPTLRVVLEHVTTA
DAVQFVRAHAASGRIAATITAHHLLINRSHIFQGGIRPHLYCLPIAKRETHRVALVEAAT
SGEGPFFLGTDTAPHTVTAKEAACGCAGCFTAANALELYAEAFDEAGALDRLEAFASLNG
PRFYNLPVSEERVALERRPSVAPDLILVSEGDAVLPFRSGETLRWSFVGAV