Protein Info for MPMX19_01251 in Azospirillum sp. SherDot2

Annotation: Modulator of FtsH protease HflK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 420 transmembrane" amino acids 66 to 89 (24 residues), see Phobius details PF12221: HflK_N" amino acids 19 to 66 (48 residues), 24.7 bits, see alignment 1.9e-09 TIGR01933: HflK protein" amino acids 89 to 367 (279 residues), 278.6 bits, see alignment E=2.5e-87 PF01145: Band_7" amino acids 91 to 280 (190 residues), 92.1 bits, see alignment E=4.4e-30

Best Hits

KEGG orthology group: K04088, membrane protease subunit HflK [EC: 3.4.-.-] (inferred from 95% identity to azl:AZL_013590)

Predicted SEED Role

"HflK protein" in subsystem Hfl operon

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.-.-

Use Curated BLAST to search for 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (420 amino acids)

>MPMX19_01251 Modulator of FtsH protease HflK (Azospirillum sp. SherDot2)
MPWNNQGGGGGGGPWGPPPGNNGPGNPWGRPQGGGNGGGGGGPQPPDLEDLLRRSQDRLR
RAMPGGFGSGRGVALVAGVLGLIWLASGIYRVEADEQGVVMRFGEWTRTEQPGLRYRLPS
PIETVLLPKVTRVNRIEVGYRSSVGGGRNDRDVPDESLMLTGDENIVDIDFTVFWVIKDA
GNFLFKIREPEVTVKKAAESAMREVIGRTDLQPALTEARQQIETSTRQLLQTMLDEYQAG
IEITQVQLQKADPPQPVIDAFNDVQRARADRERARNEAEAYRNDIIPRARGEAERLVQEA
SAYREQVVSLAQGDADRFRKVYEAYALSKDVTSKRMYLETMEEIFRGRNKIIVEGSAQNV
VPYLPLNQLAPNATPAPQQAPRQAPSNQGGNQGGARSGTQTQPLSALPQNSSQNPSMSGQ