Protein Info for MPMX19_01223 in Azospirillum sp. SherDot2

Annotation: Multidrug resistance protein NorM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 23 to 48 (26 residues), see Phobius details amino acids 68 to 89 (22 residues), see Phobius details amino acids 104 to 126 (23 residues), see Phobius details amino acids 139 to 162 (24 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details amino acids 204 to 225 (22 residues), see Phobius details amino acids 253 to 280 (28 residues), see Phobius details amino acids 291 to 311 (21 residues), see Phobius details amino acids 323 to 343 (21 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details amino acids 399 to 420 (22 residues), see Phobius details amino acids 427 to 448 (22 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 29 to 427 (399 residues), 187.8 bits, see alignment E=1.5e-59 PF01554: MatE" amino acids 29 to 187 (159 residues), 71 bits, see alignment E=9.9e-24 amino acids 270 to 413 (144 residues), 63 bits, see alignment E=2.9e-21 PF14667: Polysacc_synt_C" amino acids 141 to 222 (82 residues), 32 bits, see alignment E=1.3e-11

Best Hits

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 95% identity to azl:AZL_013930)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>MPMX19_01223 Multidrug resistance protein NorM (Azospirillum sp. SherDot2)
MSTATLPAPEPLRARLAAHIGELLRLAAPVIVSRAGLMVMMAVDTAIVGRFSAQELAYYG
LAHLPGNIMVGSGVGLLMGTVMITAHAFGAGNDADCGRAWRRSVPYALLLGVLFALVSLL
GVPLFQAGGQTAEMSAGGAHVLAVLGLGAPGMMLYITTGFFLEGVKRPWPGMVAMVIGNI
VNAALAWALVWGHAGLEPLGAVGSAWATTIVRWAMGLGLVAYVWWMRDHDRWQVRRPVSD
WWSGAARQRHLGYAAGLSIGVESGAFGGLGLFAGMISPLALGAYTVGLNLTALPFMAAVG
LASATAVRVGVAYGRGDRSDMALAGWTGLGVTSAILACVGILYRSVPDALGAIYSNDPQL
LEAVVPLIAFTAWILIADGGQTVMANALRGRHDAWIPTALHFFSYAVVMIPVSAFLVFGL
GHGAHGLFEGILIASLVSVTILSLRFAYLSRR