Protein Info for MPMX19_01023 in Azospirillum sp. SherDot2

Annotation: Bifunctional adenosylcobalamin biosynthesis protein CobP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02283: CobU
  • amino acids 11 to 172 (162 residues), 211.6 bits, E=2.9e-67

Best Hits

Swiss-Prot: 57% identical to COBP_SINSX: Bifunctional adenosylcobalamin biosynthesis protein CobP (cobP) from Sinorhizobium sp.

KEGG orthology group: K02231, adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC: 2.7.1.156 2.7.7.62] (inferred from 91% identity to azl:AZL_015930)

MetaCyc: 57% identical to CobP (Pseudomonas denitrificans (nom. rej.))
Adenosylcobinamide-phosphate guanylyltransferase. [EC: 2.7.7.62]; Adenosylcobinamide kinase. [EC: 2.7.7.62, 2.7.1.156]; 2.7.1.156 [EC: 2.7.7.62, 2.7.1.156]; 2.7.1.156 [EC: 2.7.7.62, 2.7.1.156]

Predicted SEED Role

"Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 2.7.7.62)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (32/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (30/36 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide I (8/8 steps found)
• adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (6/6 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide II (8/9 steps found)
• adenosylcobinamide-GDP salvage from cobinamide I (5/5 steps found)
• adenosylcobinamide-GDP salvage from cobinamide II (5/6 steps found)
• adenosylcobinamide-GDP salvage from assorted adenosylcobamides (1/2 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.156 or 2.7.7.62

Protein Sequence (179 amino acids)

>MPMX19_01023 Bifunctional adenosylcobalamin biosynthesis protein CobP (Azospirillum sp. SherDot2)
MMAGRMTADVTLVLGGARSGKSRYAEGLLTALGGPRVYIATSQVWDAEMAERVAKHRDDR
GPDWTTIEEPRDLTGVLRRQAAEGTGVLVDCLTLWLTNLMMAEADIAAETAALVELLPTL
PGRVVLVSNEVGLGIVPDNALARRFRDHAGRLHQSIAAVAPRVVLTVAGLPMFVKGTSI