Protein Info for MPMX19_00886 in Azospirillum sp. SherDot2
Annotation: Protoheme IX farnesyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 63% identical to COXX_PARL1: Protoheme IX farnesyltransferase (ctaB) from Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
KEGG orthology group: K02301, protoheme IX farnesyltransferase [EC: 2.5.1.-] (inferred from 92% identity to azl:AZL_012300)Predicted SEED Role
"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)
MetaCyc Pathways
- arsenite to oxygen electron transfer (2/2 steps found)
- aerobic respiration I (cytochrome c) (3/4 steps found)
- arsenite to oxygen electron transfer (via azurin) (2/3 steps found)
- aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)
- Fe(II) oxidation (2/6 steps found)
KEGG Metabolic Maps
- Biosynthesis of terpenoids and steroids
- Carotenoid biosynthesis - General
- Methionine metabolism
- Oxidative phosphorylation
- Porphyrin and chlorophyll metabolism
- Riboflavin metabolism
- Terpenoid biosynthesis
- Tryptophan metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 1.9.3.1, 2.5.1.-
Use Curated BLAST to search for 1.9.3.1 or 2.5.1.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (303 amino acids)
>MPMX19_00886 Protoheme IX farnesyltransferase (Azospirillum sp. SherDot2) MTDVTNELALNHSGGASAGDFIELLKPRVMSLVVFTGLAGIVLAPGHIHPFLALVAVLCI AVGAGASGAINMWYDRDIDAVMTRTVKRPIPSGRVEPAEALGFGVTLSVLSVVVMGLAVN WTASALLALTIGFYVFVYTMWLKRRTPQNIVIGGAAGAFPPMIGWAAVTGSVDLPSILLF LLIFLWTPPHFWALALFRNGDYTRAGVPMMPVVAGEAATKRQMLLYTLILLPVAAAPSFV GIAGPVYLAASSILGLMFVGCAVRVLRASDDKPAKKMFGFSILYLFLLFAVMMGERLILG GWA