Protein Info for MPMX19_00488 in Azospirillum sp. SherDot2

Annotation: Protease HtpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 31 to 48 (18 residues), see Phobius details amino acids 142 to 165 (24 residues), see Phobius details amino acids 177 to 200 (24 residues), see Phobius details PF01435: Peptidase_M48" amino acids 68 to 281 (214 residues), 129.8 bits, see alignment E=5.5e-42

Best Hits

Swiss-Prot: 63% identical to HTPX_XANP2: Protease HtpX homolog (htpX) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 91% identity to azl:AZL_006730)

Predicted SEED Role

"Probable protease htpX homolog (EC 3.4.24.-)" (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (332 amino acids)

>MPMX19_00488 Protease HtpX (Azospirillum sp. SherDot2)
MTSYLKTTILLAGLTAIFMAVGFLLGGKTGLIIAFVMALGMNLFSYWNSGDMVLSMYGAR
EVDAYSAPEFHGIVARLAERAGLPMPRVYIIQNDQPNAFATGRDPDHAAVAATTGLLQRL
TPEEIAGVMAHELAHVKNRDTLIMTITATIAGAVSMLGNFGLFFGGSSNDERGGNPLGMV
GAILAAILAPIAATLVQMAISRTREFEADRIGAEICGRPNWLADALTNIHNSANHIPNYQ
AEAHPATAHLFIANPLSGASMASLFSTHPDMGERVARLRAMAARTGSFSSGLGGGGFGGG
QTPPRDGRSPWGAPPQGGQGGFMPQNRRGPWG