Protein Info for MIT1002_04103 in Alteromonas macleodii MIT1002

Annotation: Galactose operon repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 333 PF00356: LacI" amino acids 3 to 48 (46 residues), 67.8 bits, see alignment 1.1e-22 PF00532: Peripla_BP_1" amino acids 59 to 305 (247 residues), 92.6 bits, see alignment E=6.5e-30 PF13407: Peripla_BP_4" amino acids 62 to 273 (212 residues), 58.3 bits, see alignment E=1.8e-19 PF13377: Peripla_BP_3" amino acids 169 to 328 (160 residues), 110.8 bits, see alignment E=1.5e-35

Best Hits

Swiss-Prot: 39% identical to GALR_ECOLI: HTH-type transcriptional regulator GalR (galR) from Escherichia coli (strain K12)

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 89% identity to amc:MADE_04075)

Predicted SEED Role

"Transcriptional regulator of beta-glucosides utilization, LacI family" in subsystem Beta-Glucoside Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (333 amino acids)

>MIT1002_04103 Galactose operon repressor (Alteromonas macleodii MIT1002)
MPTIYQVAERAGVSLSTVSRVLNGKASVNKVLKERVEKAVKELNYRPNSVARSLANNRTD
SVGVLVPELNAPFFGDLMQAVESTLRAADKHVIISVGRNCLETEKDAVEFLISRNCDALI
MHAEALSDEYLLELNQSKLPVALVNRQVEGLPEACTSLDNEKGGYLATRHLLELGHKDIA
YISGPTDKCDASLRLEGHKRALSEAGLPTNPQLIFNGDYSEEDGKIGLLELMARDVPFTA
LVCANDWMASGAISCARDLGMSLPHDLSVVGFDDVVFAHHVFPRLTTVSNPIAEMAEMSA
KYILNKVYGQANNVQLYFEPSLVVRESTVKHEG