Protein Info for MIT1002_03989 in Alteromonas macleodii MIT1002

Annotation: Succinate semialdehyde dehydrogenase [NAD(P)+] Sad

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 3 to 454 (452 residues), 468.9 bits, E=7.6e-145

Best Hits

Swiss-Prot: 44% identical to SAD_ECOLI: Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (sad) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 95% identity to amc:MADE_03968)

MetaCyc: 44% identical to succinate semialdehyde dehydrogenase (NAD(P)+) Sad (Escherichia coli K-12 substr. MG1655)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.24, 1.2.1.20]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• GABA shunt II (3/4 steps found)
• 4-aminobutanoate degradation I (1/2 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• GABA shunt I (2/4 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• superpathway of 4-aminobutanoate degradation (1/3 steps found)
• L-lysine degradation IV (1/5 steps found)
• L-lysine degradation III (1/6 steps found)
• L-lysine degradation X (1/6 steps found)
• L-lysine degradation I (1/7 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (4/13 steps found)
• superpathway of L-lysine degradation (7/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.24

Protein Sequence (462 amino acids)

>MIT1002_03989 Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (Alteromonas macleodii MIT1002)
MSETINTYNPATGEKIDHYHLMSAEDAEQAVTRSQEAYLNWRRTSFETRADLFNNLANLM
EERIDDLASLMTREMGKVTAQGKQEVQLCAEICRYTAEHGASILEDEHRIFEGGRAIITY
QPIGVILGIQPWNFPLYQVIRYSASNIMAGNTTVLKHAKNVFGMAQAIQQMYEDAGFPKN
VYQSLLIDGSTASDLIKHKHVRGVTFTGSDEVGKEVAKEAASLSKKTVMELGSNDAFLVL
EDADIDHAVEMCIQGRVINNGETCVAAKRFVIVDSVYDEFRDKFVAQCKKLKVGDPTNEN
TDLGPMAREDLRDELHEQVKKSLENGATLSLGGEIPDSDGYFYPITVLEDVSPGMPAYDD
ELFGPVASLIRVRDDKQAMEVANDSRYGLGGGIFSTDTDKAIALAKDEFDTGMVNINGYS
LAQPNLPFGGVKDSGYGREHGGYGMREFVNIKTIMVAEKSAE