Protein Info for MIT1002_03905 in Alteromonas macleodii MIT1002

Annotation: Biosynthetic arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 4 to 635 (632 residues), 720.3 bits, E=1e-220
• PF02784: Orn_Arg_deC_N
  • amino acids 91 to 343 (253 residues), 136.9 bits, E=1.2e-43
• PF17810: Arg_decarb_HB
  • amino acids 371 to 451 (81 residues), 59.2 bits, E=6.1e-20
• PF17944: Arg_decarbox_C
  • amino acids 581 to 634 (54 residues), 37.8 bits, 3.2e-13

Best Hits

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 97% identity to amc:MADE_03894)

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• spermidine biosynthesis III (1/4 steps found)
• superpathway of putrescine biosynthesis (1/4 steps found)
• superpathway of polyamine biosynthesis II (3/8 steps found)
• superpathway of arginine and polyamine biosynthesis (9/17 steps found)
• superpathway of polyamine biosynthesis I (1/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (4/13 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Protein Sequence (636 amino acids)

>MIT1002_03905 Biosynthetic arginine decarboxylase (Alteromonas macleodii MIT1002)
MSDWSIEEAERVYGVSQWGGGYFQIGENGNVHITPVPEDPSIRIDFNSVIEDIRKEGVQF
PVVVRFHDILRSQVAGLNKAFRSSIEEAEYQGQYQGVYPVKVNQMREVVEEIVDAGKPFN
YGLEAGSKAELLTVLAMNTNEESLTILNGYKDDEVMRLALLGRKLGRRVVVVVEKYTELL
LLVKIAKELDIDPIIGVRSKMTVKGRGKWESSGGERAKFGLTITEIINAARYLEEQGMAH
CLKLLHFHIGSQLTDIRAVKEAVTEGARIYADLHKMGFELDYVDVGGGLGIDYDGSNSTN
ESSRNYSMQEYVADVVYGMKEMCDLEGVPHPHLVSESGRAITAHHSCVITEIVGEIKSNA
SQMDTSAKAGEHFFLKNMRELADTFDEQTNMHEIYNDASQYKEQALDAFKLRVLSLEELG
KIETLYWQIMGRLQQWYRNEEYVPEELQELDYSLSSQYLCNFSVFQSAADTWAIDQLLPV
VPLIRMNEEPTVNCSLVDITCDSDGKIDQFTIGREITDVLPMHPLKKDEPYYIGLFLTGA
YQDVMGDMHNLFGRLNEVHIYSYDDDPEDFYIEEVVKGSSVEDVLNVMQYNPRAMASDVK
RMIDKQVWDGKLNPREGVRWTDFYENCLAGYTYLKQ