Protein Info for MIT1002_03893 in Alteromonas macleodii MIT1002

Annotation: Autoinducer 2 sensor kinase/phosphatase LuxQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 641 transmembrane" amino acids 7 to 27 (21 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details PF00672: HAMP" amino acids 200 to 247 (48 residues), 28.9 bits, see alignment 2.4e-10 PF00512: HisKA" amino acids 258 to 323 (66 residues), 73.1 bits, see alignment E=3.2e-24 PF02518: HATPase_c" amino acids 371 to 487 (117 residues), 104 bits, see alignment E=1.3e-33 PF00072: Response_reg" amino acids 516 to 628 (113 residues), 83.4 bits, see alignment E=2.7e-27

Best Hits

KEGG orthology group: None (inferred from 88% identity to amc:MADE_03837)

Predicted SEED Role

"putative sensor protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (641 amino acids)

>MIT1002_03893 Autoinducer 2 sensor kinase/phosphatase LuxQ (Alteromonas macleodii MIT1002)
MRIKSKLLVIYIPILLIGMALTGYWAYLTAYDSVREREYQLLTQTLTLNVLEIIDERREL
LIESGLENVPVFREAYQKEVFEELKSLQQATDRHFAISDKSADTVVFSTMEHTVVPNVED
ATIATIASRKVAFGESNINDADVLFACAEFAPWNWKVTVLQPADALQSFLSTIAWLTSLV
TLFAVVIVSLLMGRVTQVFVVSPIEKIKSAASRIAVDHKKVSIDLQQNDELGSLARDVEA
MSGEIEQYVAQAQQANRAKTDFLAVMSHEIRTPLNGIQGLATLLLDTHLSDKQHQYASDL
KSSASILATVINDVLDLSKIESGMSEVDVTEFDLDAMLNDLITLLGTNASANSTRLVYKS
KNMESVAVTSDITKLRQIIINLVSNAIKFTHKGTVTISAKLKQPSQDTVSENHLVIAVKD
TGIGIEPDRLEHIFDKFTQSDSSITRKYGGTGLGLAIAKQLAQILGGDIKVVSKVGEGSC
FTVTAKVQSRRVVESSADSGSVRQAERASLPEGIKVLLAEDNAINAVVAQALLEQLKCDV
EHVDNGLKAAARVEEGGIDVVFMDVHMPVMDGIEATKRIRKLDGELSKTPVIGLTAEAFK
ERHVSFKEAGMDDIVTKPVTVEALQESLSKLALNQEVTDNS