Protein Info for MIT1002_03772 in Alteromonas macleodii MIT1002

Annotation: Homocysteine S-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02574: S-methyl_trans
  • amino acids 9 to 298 (290 residues), 207.8 bits, E=1.6e-65

Best Hits

KEGG orthology group: None (inferred from 74% identity to amc:MADE_00664)

Predicted SEED Role

"Homocysteine S-methyltransferase (EC 2.1.1.10)" in subsystem Methionine Biosynthesis (EC 2.1.1.10)

MetaCyc Pathways

• L-methionine salvage from L-homocysteine (2/3 steps found)
• S-methyl-L-methionine cycle (1/2 steps found)
• superpathway of L-methionine salvage and degradation (6/16 steps found)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.10

Use Curated BLAST to search for 2.1.1.10

Protein Sequence (299 amino acids)

>MIT1002_03772 Homocysteine S-methyltransferase (Alteromonas macleodii MIT1002)
MKEGMHDILILDGGMGRELKKTGAPFKQPEWSALTLMQTPELVSDVHKRFLEAGACVITT
NAYALVPFHIGENTFKEQAFTLAQSAAELARSAVNALKSDGDNKRFVAGSVPPAFGSYRP
DLFDASRVADILTPLIKAQEPYVDVWLIETASSVEEAEAVVSLIKQHSSLPLWLSFSVSN
RETSNEPVTLRSGEPLSEIASILSEVQSVLFNCSQPEEMEDAISITRSLNTSINIGAYAN
SFSERKRTHAANALLSEIRDDITPARYVEYVKTWVAAGATIIGGCCGIGPEHIKAISDV