Protein Info for MIT1002_03764 in Alteromonas macleodii MIT1002

Annotation: ATP-dependent helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 877 PF00270: DEAD" amino acids 31 to 247 (217 residues), 77.7 bits, see alignment E=2.2e-25 TIGR04121: DEXH box helicase, DNA ligase-associated" amino acids 118 to 855 (738 residues), 972.6 bits, see alignment E=5.9e-297 PF00271: Helicase_C" amino acids 299 to 400 (102 residues), 65.3 bits, see alignment E=1.4e-21 PF19306: WH_Lhr" amino acids 429 to 598 (170 residues), 138.9 bits, see alignment E=2.8e-44 PF08494: DEAD_assoc" amino acids 647 to 830 (184 residues), 149.6 bits, see alignment E=2.5e-47

Best Hits

KEGG orthology group: K03724, ATP-dependent helicase Lhr and Lhr-like helicase [EC: 3.6.4.-] (inferred from 92% identity to amc:MADE_00670)

Predicted SEED Role

"FIG003033: Helicase domain protein"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (877 amino acids)

>MIT1002_03764 ATP-dependent helicase (Alteromonas macleodii MIT1002)
MTSLPSVFAHWFEQKGWQLRDYQHTMLVEKDQHDCTLLIAPTGAGKSLSGFLPSLVELAE
TFGMSELAETFGMSELAETFGMSELAEMSENGELVKKTGTSEQAETKAINKQATKGKEKD
GFNGLHTLYISPLKALTQDIHRNLLQPIEEMALPITAETRTGDTPSHKRQRQRKKPPNIL
LTTPESLMLMLSYADADKLFGKLKRVIIDETHSLMANKRGDFLSLALARLSVLSPHCKRI
GLSATVAFPETLGAWLAGSDGVANIVKVKAGEKPKVEMLHSKARMPFGGFMARYAIDDIY
QAIENAKTTLVFVNTRAQSELLFQMLWEANKAALPIALYHGSLSKEQRRKTEAMMASGML
RAIVCTSALELGIDWGDVDKVIQVGAPKGVSRLLQRIGRANHRLDEPSEALLVPANRFEA
LECQAAITAIEKGELDGESPQPGALDIVPQFILNCLCSRADSPDTLYKEILTATPYQGLD
RDDFDKLWQFTQDGGSALNAYERYQRLTKNDDGTYSPANRRVIQRHRQNIGTIVEAGRLK
VKRIRRGNQGKIIGEVEEYFAQQLTPGDTFYFAGEVLRFEAIRDMQLHAKPAKAKEPKIP
SYAGGQMPLSTYLADGVRAILATQKSWRALPAQVQEWLKLQQAFSQLPSPDNVLVEQFPF
RQAHYTLYYTFDGRKANQTLGMLLTRRMEKMGIKPLSFSVTDYGLSVASVNAITQGQLQQ
LFQPDILGDELEDWMLQAPMLKRSFRQVAVVSGLTEQRYHASQKTMKQVTFSTDLIYDTL
REHDRDHILLKVARADAERELLDLRRLANLLIRYVDSTTLVNLEKPSPMAIPIVLDVRSE
QVKGAGAQAIIEQANLYAEAETMLDEVRALLSGSSVE