Protein Info for MIT1002_03743 in Alteromonas macleodii MIT1002

Annotation: Putative multidrug export ATP-binding/permease protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 613 transmembrane" amino acids 37 to 61 (25 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 159 to 178 (20 residues), see Phobius details amino acids 184 to 203 (20 residues), see Phobius details amino acids 266 to 291 (26 residues), see Phobius details PF00664: ABC_membrane" amino acids 43 to 307 (265 residues), 83.7 bits, see alignment E=2.8e-27 PF00005: ABC_tran" amino acids 382 to 535 (154 residues), 119.3 bits, see alignment E=3e-38

Best Hits

Swiss-Prot: 56% identical to Y1051_HAEIN: Uncharacterized ABC transporter ATP-binding protein HI_1051 (HI_1051) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 97% identity to amc:MADE_00688)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (613 amino acids)

>MIT1002_03743 Putative multidrug export ATP-binding/permease protein (Alteromonas macleodii MIT1002)
MFSFFEKLTQPFPDTPPTQPPTGIVAFCKYYTKGMWGVILTVSVLSAIVAMLEVALFGFL
GQLVDWFSDQNRATFLADQKFTLIGMGLTVLVFIPLFILLRSLFSRQSLMGNYPMRIRWQ
AHRYLLGQSLTFFHDEFAGRVATKVMQTALSVRETVTKVLDLLVYISVYFISMVVLIFST
DWRLAMPLIVWFFVYIGILKVLVPKLKEVSQKQADARSLMTGRIVDSYTNITTVKLFSHS
RREADYAKESMDGFLKTVYPQMRLVTVLEFCVEMANAILIFTIGALSVYLWMENIASPGD
IAIAISLCLRLNGMSHWVMWEVSGLFENLGTVQDGMNTLAQPIAVKDKPKADALKVNGGG
INFDNVHFSYSGADNKPIDVFTNLDLAIKPGEKVGLVGRSGAGKSTLVNLLMRFYDTQSG
RIVIDGQDITEVGQETLRAKISMVTQDTSLMHRSVRDNILYGRTDATEEDMIRAAKQAEA
HDFILTLTDSHGRTGYDAHVGERGVKLSGGQRQRIAIARVLLKDAPVLVLDEATSALDSE
VEAAIQACLDKVMEGKTVLAIAHRLSTIAQMDRLLVLDKGNIVEQGTHTELIAHNGIYAK
LWAHQTGGFIGVE